IndraLab

Statements

CD40 activates CYLD. 2 / 2
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"More specifically, it has been shown that CYLD constitutes a key negative regulator of NF-kappaB and JNK in macrophages from Cyld null mice that have been treated with CD40 or ligands against TLR4 and TLR2 XREF_BIBR."
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"In multiple myeloma, high-density oligonucleotide array CGH and gene expression profiling data revealed ten genes causing the inactivation of TRAF2, TRAF3, CYLD, and IAP1 and cIAP2, and activation of NFKB1, NFKB2, CD40, LTBR, TACI, and NIK was linked to constitutive activation of the noncanonical NF-kappaB pathway."
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