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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CD40 activates CYLD. 2 / 2

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"More specifically, it has been shown that CYLD constitutes a key negative regulator of NF-kappaB and JNK in macrophages from Cyld null mice that have been treated with CD40 or ligands against TLR4 and TLR2 XREF_BIBR."

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"In multiple myeloma, high-density oligonucleotide array CGH and gene expression profiling data revealed ten genes causing the inactivation of TRAF2, TRAF3, CYLD, and IAP1 and cIAP2, and activation of NFKB1, NFKB2, CD40, LTBR, TACI, and NIK was linked to constitutive activation of the noncanonical NF-kappaB pathway."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...