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USP10 binds FLT3. 8 / 8
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"The data in our report demonstrated that ATO treatment reduces the binding of USP10 to FLT3 protein, which might partly contribute to the enhanced ubiquitination of mutant FLT3 protein.Hsp90 is an important chaperone molecule assisting in folding and preventing client proteins from ubiquitination and degradation [44]."
30250637
sparser
"A similar interaction between USP10 and FLT3 was demonstrated in 293T cells engineered to exogenously express these proteins ( xref )."
28967922
reach
"Co-immunoprecipitation assays showed that ATO treatment led to significantly reduced binding of USP10 with FLT3 protein in TF1/ITD-Ub cells."
30250637
sparser
"Co-immunoprecipitation assays showed that ATO treatment led to significantly reduced binding of USP10 with FLT3 protein in TF1/ITD-Ub cells."
30250637
sparser
"The data in our report demonstrated that ATO treatment reduces the binding of USP10 to FLT3 protein, which might partly contribute to the enhanced ubiquitination of mutant FLT3 protein."
30250637
sparser
"Our current data also support our previous observation that FLT3 and USP10 bind to one another, xref as FLT3 and USP10 co-immunoprecipitate in Ba/F3-FLT3-ITD cells (an AKT immunoprecipitation was included as a control for nonspecific binding) (Fig.  xref , lower panel)."
32015510
sparser
"ATO facilitates poly-ubiquitination and degradation of FLT3 partly through reducing the binding of mutant FLT3 to the deubiquitinating enzyme USP10."
30250637
sparser
"We observed robust co-immunoprecipitation (co-I.P.) of USP10 with FLT3 in Ba/F3-FLT3-ITD cells; reverse co-I.P. studies confirmed the association of FLT3 with USP10 ( xref )."
28967922