IndraLab

Statements

sparser
"In this study, using an oxidative damage model in RPE cells, we identified a novel oxidation-related lncRNA named CYLD-AS1."
36165267
sparser
"We further revealed that the expression of CYLD-AS1 was increased in RPEs during oxidative stress."
36165267
sparser
"Depletion of CYLD-AS1 promoted cell proliferation and mitochondrial function and protected RPE cells against hydrogen peroxide (H 2 O 2 )-induced damage."
36165267
sparser
"Oxidative stress-induced lncRNA CYLD-AS1 promotes RPE inflammation via Nrf2/miR-134-5p/NF-κB signaling pathway."
36165267
sparser
"In summary, our study revealed that CYLD-AS1 affects the oxidative stress-related and inflammatory functions of RPE cells by sponging miR-134-5p to mediate NRF2/NF-κB signaling pathway activity, suggesting that targeting CYLD-AS1 could be a promising strategy for the treatment of AMD and related diseases."
36165267
sparser
"Remarkably, these two signaling pathways were mediated by the CYLD-AS1 interactor miR-134-5p."
36165267
sparser
"Moreover, exosomes secreted by CYLD-AS1 knockdown RPE cells had a lower proinflammatory effect than those secreted by control cells."
36165267
sparser
"Mechanistically, CYLD-AS1 also regulated the expression of NRF2, which is related to oxidative stress, and NF-κB signaling pathway members, which are related to inflammation."
36165267