IndraLab

Statements

CYLD translocates. 5 / 5
| 5
reach
"Translocation of activated CYLD to the perinuclear region of the cell is achieved by an inhibitory interaction of CYLD with histone deacetylase-6 (HDAC6) leading to an increase in the levels of acetylated alpha-tubulin around the nucleus."
19893491
reach
"It is not clear, however, how CYLD translocates to the perinuclear region to capture Bcl-3 and whether this is the only mechanism by which CYLD regulates tumour cell proliferation."
19893491
reach
"In the absence of TSA, CYLD localized throughout the cytoplasm (XREF_FIG), while in the presence of TSA or in HDAC6 depleted cells, the levels of acetylated tubulin increased and CYLD translocated to the perinuclear region where it strongly colocalized with acetylated MTs (XREF_FIG and XREF_SUPPLEMENTARY)."
19893491
reach
"CYLD inducibly translocates to a perinuclear region where it binds to the IkappaB family member Bcl-3 and removes K63 linked polyubiquitin chains, thus preventing nuclear translocation of Bcl-3-p50 and Bcl-3-p52 complexes [XREF_BIBR]."
21119682
reach
"When HDAC6 is silenced or knocked down, acetylated alpha-tubulin is increased, acetylated MTs are accumulated, and CYLD is translocated to the perinuclear region, leading to a reduced interaction between CYLD and BCL3 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
30176876