IndraLab

Statements

UCHL1 activates proteolysis. 8 / 8
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"Thus, UCH-L1 deficiency impairs ubiquitin dependent protein degradation and results in accumulation of highly ubiquitinated proteins."
20980462
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"In this study, we found a novel therapeutic target, UCHL1, can modulate SMN protein degradation."
20713032
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"However, data here unequivocally demonstrate that acute disruption of UCHL1 function leads to an impairment in ubiquitin dependent protein degradation in vivo."
28397067
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"The significance of the protein knots in the mechanostability of UCHL1 was indirectly assessed by N-terminal truncation (UCHL1 ) that essentially unknotted the 5 knotted topology, resulting in a profound acceleration of the ClpXP-mediated proteolysis."
29728659
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"Decreasing the activity of UCHL1 in UPS, has been reported to ablate the protein degradation activity induced by UCHL1 and to increase the levels of highly ubiquitinated proteins, both of which can ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20713032
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"Based on the key enriched GO items, we supposed that miR-1246 targets UBE-2C and UCHL1 for the regulation of ubiquitin mediated proteolysis and, therefore, persuades the prognosis of LUAD patients."
33050659
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"Also known as UCHL1, PGP9.5 prevents protein degradation by the proteosome-dependant pathway by removing ubiquitin from ubiquitinated proteins [XREF_BIBR]."
25066711
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"In contrast, if UCHL1 upregulation promotes proteolysis in K256E- ACTN4 pod + / UCHL1 +/+ mice, K256E-α-actinin-4 aggregates can be degraded via the UPS."
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