IndraLab

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UCHL1 activates proteolysis. 8 / 8
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"Based on the key enriched GO items, we supposed that miR-1246 targets UBE-2C and UCHL1 for the regulation of ubiquitin mediated proteolysis and, therefore, persuades the prognosis of LUAD patients."
33050659
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"However, data here unequivocally demonstrate that acute disruption of UCHL1 function leads to an impairment in ubiquitin dependent protein degradation in vivo."
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"In this study, we found a novel therapeutic target, UCHL1, can modulate SMN protein degradation."
20713032
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"Decreasing the activity of UCHL1 in UPS, has been reported to ablate the protein degradation activity induced by UCHL1 and to increase the levels of highly ubiquitinated proteins, both of which can ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20713032
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"Thus, UCH-L1 deficiency impairs ubiquitin dependent protein degradation and results in accumulation of highly ubiquitinated proteins."
20980462
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"Our data suggest that UCHL1 upregulation in ACTN4 associated FSGS fuels the proteasome and that UCHL1 deletion may impair proteolysis and thereby preserve K256E and wt-alpha-actinin -4 heterodimers, maintaining podocyte cytoskeletal integrity and protecting the glomerular filtration barrier."
24662305
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"The significance of the protein knots in the mechanostability of UCHL1 was indirectly assessed by N-terminal truncation (UCHL1 ) that essentially unknotted the 5 knotted topology, resulting in a profound acceleration of the ClpXP-mediated proteolysis."
29728659
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"Also known as UCHL1, PGP9.5 prevents protein degradation by the proteosome-dependant pathway by removing ubiquitin from ubiquitinated proteins [XREF_BIBR]."
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