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CD44 binds TGFB1. 19 / 19
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"We performed a variety of functional tests using TGF-beta1, TGF-beta1 inhibitor, and CD44 knockdown and identified a direct interaction between CD44 and TGF-beta1 in EMT induction.The human HCC cell l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The effect on TGF-beta1 is not unexpected as activated CD44 interacts with TGF-beta1 to promote myofibroblast differentiation and a fibrogenic phenotype, which promotes subsequent deposition of interstitial collagens."
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"In other research, CD44 + cancer stem-like cells can switch to EMT cells via TGFβ1-CD44 signaling and drive PCa metastasis xref ."
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"In the HA-rich environment, a synergistic interaction between TGF-b1, HA, and CD44 facilitates EGFR/CD44 coupling, which is essential for the proliferative effects of TGF-b1 [ 52 , 53 ]."
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"Interestingly, one study demonstrated synergistic interactions of CD44 and TGF-β1 in EMT induction via the Akt/GSK-3β/β-catenin pathway in HCCs ( xref )."
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"A recent study found that CD44 protein levels were enhanced by TGF-β1 treatment and that synergistic interactions between CD44 and TGF-β1 induced EMT and CSC phenotypes through Akt/GSK-3β/β-catenin signaling axis in HCC [ xref ]."
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"However, it remains unclear how CD44 interacts with TGF-beta1 during EMT induction."
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"In the HA-rich environment, a synergistic interaction between TGF-b1, HA, and CD44 facilitates EGFR/CD44 coupling, which is essential for the proliferative effects of TGF-b1 [ 52 , 53 ]."
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"By testing high expression CD44 HCC cells with differential TGF-beta1 expression, we confirmed that EMT induction and tumor aggressiveness are tightly regulated by interactions between CD44 and TGF-be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A recent study found that CD44 protein levels were enhanced by TGF-beta1 treatment and that synergistic interactions between CD44 and TGF-beta1 induced EMT and CSC phenotypes through Akt/GSK-3beta/beta-catenin signaling axis in HCC [XREF_BIBR]."
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"The majority of HCC cells express high levels of CD44 [14,22] , which are highly associated with TGF-β1 expression [24] ."
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"We performed a variety of functional tests using TGF-β1, TGF-β1 inhibitor, and CD44 knockdown and identified a direct interaction between CD44 and TGF-β1 in EMT induction."
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"The current study aimed to elucidate their interactions by using two CD44-expressing HCC cells with differential TGF-β1 expression levels."
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"To further delineate the effects of TGF-β1-CD44 interactions on EMT, we first evaluated whether EMT could be induced by TGF-β1 treatment in SNU-354 cells intrinsically lacking TGF-β1 expression, which[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, it remains unclear how CD44 interacts with TGF-β1 during EMT induction."
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"By testing high expression CD44 HCC cells with differential TGF-β1 expression, we confirmed that EMT induction and tumor aggressiveness are tightly regulated by interactions between CD44 and TGF-β1."
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"The effect on TGF-β1 is not unexpected as activated CD44 interacts with TGF-β1 to promote myofibroblast differentiation and a fibrogenic phenotype, which promotes subsequent deposition of interstitial collagens."
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"The 10 top downregulated miRNAs in terms of LFC ranged between miR-1306-3p (UMI = 2.0; LFC −2.705) modulating FBXL5 [ xref ] and miR-1275 (UMI = 8.0 LFC −2.007) targeting IGFBP1/2/3/E1F5A2 [ xref , xref , xref , xref , xref ] and, in general, were less referenced, except for mIR-491-5p (UMI = 3.0; LFC −2.488) targeting PKM2 and SEC61A1/EGFR [ xref , xref , xref ] and miR-221-5p (UMI = 2.0; LFC −2.146) targeting ITGB5/GCDH and CD44-TGF-B1 [ xref , xref , xref , xref ] (see xref )."
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"CD44 has emerged as an LCSC marker that strongly induces EMT together with TGF-β1. xref recently reported synergistic interactions between CD44 and TGF-β1 in EMT induction and CSC properties through the AKT/GSK-3β/β-catenin pathway in HCC cells."
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