IndraLab

Statements

Quercetagetin inhibits MAPK8. 8 / 8
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"Quercetagetin inhibited JNK1 activity more strongly than did quercetin, myricetin, kaempferol, or SP600125."
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"Overall, our crystallographic findings, the accompanying biochemical data, and the cell based and animal model data show that quercetagetin is a strong inhibitor of JNK1 and PI3-K and might have practical implications for the prevention or therapy of cancer and other chronic diseases."
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"To investigate the molecular basis of the inhibition of JNK1 by quercetagetin (XREF_FIG), we determined the crystal structure of the JNK1-pepJIP1-quercetagetin ternary complex, where pepJIP1 is a docking site peptide fragment of the scaffold protein JIP1."
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"Only quercetagetin strongly suppressed JNK1 activity."
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sparser
"To investigate the molecular basis of the inhibition of JNK1 by quercetagetin ( xref ), we determined the crystal structure of the JNK1–pepJIP1–quercetagetin ternary complex, where pepJIP1 is a docking site peptide fragment of the scaffold protein JIP1."
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"In vitro JNK1 kinase assays revealed that quercetagetin inhibited JNK1 activity more potently than did SP600125 (a pharmacological JNK1 inhibitor)."
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"The recent discovery of c-Jun NH2-terminal kinase JNK1 suppression by natural quercetagetin (1) is a promising lead for the development of novel anticancer agents."
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"Quercetagetin attenuated JNK1 activity with an IC50 value of 4.6 muM , which is even more potent than SP600125 ( IC50 = 5.2 muM ) , in the immobilized metal ion affinity-based fluorescence polarization assay ."
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