IndraLab

Statements


14 7 | 3 7

No evidence text available

No evidence text available

No evidence text available

sparser
"In the same assay, an H 6 -tagged fusion protein of PDZ1-2 of PSD-95 bound specifically to Kv1.4 ( Figure 1B , right)."

No evidence text available

reach
"To determine whether inhaled anesthetics disrupt PDZ domain-mediated protein-protein interactions in a physiological setting, we used a co-immunoprecipitation assay to detect in vivo binding of PSD-95 to Kv1.4."

No evidence text available

No evidence text available

No evidence text available

sparser
"Although direct interaction of E-dlg PDZ domains with Kv1.4 has yet to be demonstrated, these data are consistent with a function for E-dlg in regulating development and transmission in the synapse."

No evidence text available

No evidence text available

No evidence text available

No evidence text available

sparser
"When domains that mediate the interaction of Kv1.4 and PSD-95 were disrupted, Kv1.4 localized nonspecifically."

No evidence text available

reach
"The interaction between Kv1.4 and PSD-95 was proposed to be critical for the axonal targeting of Kv1.4 channels (Arnold and Clapham, 1999)."

No evidence text available

No evidence text available

sparser
"Defined substitutions within the four C-terminal residues could abolish Kv1.4 interaction with PSD-95 (as measured in the yeast two-hybrid assay), and all the mutations that abolished Kv1.4 binding to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

No evidence text available

sparser
"However, the yeast cell growth was slowed by halothane ( xref ) and isoflurane ( xref ) in a dose-dependent manner, indicating that these anesthetics dose-dependently inhibit PDZ domain-mediated protein-protein interactions between PSD-95 and Kv1.4."

No evidence text available

sparser
"The strength of this interaction in the yeast two-hybrid system was similar to the binding of the Shaker-type K + channel Kv1.4 to the PDZ1+2 domains of PSD-95."

No evidence text available

No evidence text available

sparser
"To determine whether inhaled anesthetics disrupt PDZ domain-mediated protein-protein interactions in a physiological setting, we used a co-immunoprecipitation assay to detect in vivo binding of PSD-95 to Kv1.4."

No evidence text available

No evidence text available

reach
"However, the yeast cell growth was slowed by halothane (Fig. 1, A and B) and isoflurane (Fig. 1, C–E) in a dose-dependent manner, indicating that these anesthetics dose-dependently inhibit PDZ domain-mediated protein-protein interactions between PSD-95 and Kv1.4."

No evidence text available