IndraLab

Statements


ERK leads to the phosphorylation of STAT3 on Y705. 3 / 3
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"Inhibition of ERK activation by AZD6244 leads to derepression of STAT3, as ERK mediated STAT3 (S727) phosphorylation negatively modulates STAT3 tyrosine phosphorylation at Y705 which is required for dimer formation, nuclear translocation, and DNA binding activity of this transcriptional regulator."

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"Inhibition of MEK and ERK with U0126 totally blocked the phosphorylation of STAT3 (Tyr705 and Ser727) but increased the phosphorylation of CREB and ATF1 (XREF_FIG)."

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"The activity of ERK1/2 in leptin and OB3 co-treated cells was inhibited by PD98059 and further reflected in leptin induced phosphorylation of STAT3 Tyr 705 and ERalpha."