IndraLab
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reach
"In brain cortex, increased UA : (1) reduced tMCAO induced increases in Vegfa and Mmp9 and Timp1 ratio expressions; (2) induced Sod2 and Cat expressions and reduced MDA levels; (3) induced Il6 expression, upregulated STAT3 and NF-kappaB p65 phosphorylation, induced Socs3 expression, and inhibited microglia activation; and (4) ameliorated the Bax and Bcl -2 ratio and induced a reduction in caspase-3 cleavage as well as in TUNEL positive cell counts."
reach
"The relationship between IL-6 and STAT3 has been reported by Yadav et al (2011) XREF_BIBR, where the researchers showed that the over-expression of IL-6 in immortalized oral epithelial cells enhances the phosphorylation of STAT3; this can then induce EMT changes in oral epithelial cells."