IndraLab

Statements

Modified IL6 leads to the phosphorylation of STAT3. 17 / 17
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"We investigated if increased IL-6 levels in CM of MSCs after miR-1246 overexpression would lead to increased Stat3 phosphorylations in Jak-Stat-negative breast cancer and epithelial cell lines [XREF_BIBR]."
28159925
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"Recent evidence has shown that ADCS provoke an increase in IL6 levels, which induces the phosphorylation of JAK2 and STAT3 16, resulting in proliferation, invasion and tumor growth in prostate and endometrial cancers."
32848147
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"Given that the amounts of IL-6 and IL-10 by Pam3CSK4 alone treated macrophages was unable to induce STAT3 phosphorylation (XREF_FIG), it is highly unlikely that sustained phosphorylation of STAT3 in STAT1-null macrophages involved dysregulated production of IL-6 and/or IL-10."
26299368
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"Thus, aberrantly high IL-6 levels cause the phosphorylation of STAT3 [XREF_BIBR], leading to cancer cell survival [XREF_BIBR, XREF_BIBR]."
24098947
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"Because STAT3 activation through IL-6 has previously been implicated in mediating Teff resistance, we also investigated the surface expression of IL-6R as well as IL-6- and TCR mediated phosphorylation of STAT3 in T cells from our study subjects."
30006377
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"Studies found that moderate levels of TNF-alpha or IL-6 can increase the phosphorylation of STAT3 at Try705, and this is Brg1 dependent [XREF_BIBR, XREF_BIBR]."
23853776
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"Next, we tested whether these levels of IL-6 are sufficient to induce STAT3 phosphorylation in muscle fibers."
28264935
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"STAT3 phosphorylation can be upregulated by exogenous IL-6, therefore, we sought to determine the effect of bazedoxifene on the expression of IL-6 stimulated STAT3 phosphorylation."
29207075
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"Most importantly, IL-6 could activate STAT3 in a time dependent manner in cultured cardiomyocytes, and inhibition of IL-6 level by anti-IL-6-neutralizing antibody clearly attenuated ISO induced phosphorylation of STAT3 in myocardium."
12665506
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"In brain cortex, increased UA : (1) reduced tMCAO induced increases in Vegfa and Mmp9 and Timp1 ratio expressions; (2) induced Sod2 and Cat expressions and reduced MDA levels; (3) induced Il6 expression, upregulated STAT3 and NF-kappaB p65 phosphorylation, induced Socs3 expression, and inhibited microglia activation; and (4) ameliorated the Bax and Bcl -2 ratio and induced a reduction in caspase-3 cleavage as well as in TUNEL positive cell counts."
32959172
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"Importantly, muscle STAT3 phosphorylation was not increased by systemic IL-6 overexpression (XREF_FIG)."
25555992
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"Exosomes from macrophages exposed to apoptotic cancer cells have increased amounts of IL-6 that increases the phosphorylation of STAT3, which likely explains the increased transcription of STAT3 target genes such as CyclinD1, MMP2 and MMP9."
31281466
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"Conversely, knockdown of FN EGF or IL-6 expression suppressed STAT3 phosphorylation in resistant BT474R and NCI-N87R cells, resulting in partial rescue of sensitivity of these cells to trastuzumab treatment."
25327561
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"STAT3 activation may increase IL-6 expression, which in turn may lead to STAT3 phosphorylation, resulting in diverse biological responses XREF_BIBR."
25198511
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"XREF_BIBR Additionally, in the case of IL-6 it was recently shown that F4/80 tumor infiltrating macrophages secreted high amounts of IL-6, which increased STAT3 phosphorylation and cellular growth in the tumor cells."
22258147
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"Hypoxia increased serum IL-6 levels, which in turn increased JAK2 and STAT3 phosphorylation, which subsequently upregulated MMP-9."
32047820
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"The relationship between IL-6 and STAT3 has been reported by Yadav et al (2011) XREF_BIBR, where the researchers showed that the over-expression of IL-6 in immortalized oral epithelial cells enhances the phosphorylation of STAT3; this can then induce EMT changes in oral epithelial cells."
24533098