IndraLab

Statements

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"As we expected, the MTT assay results showed that overexpression of CYLD obviously decreased the proliferation of A549 cells or H460 cells compared with that of untreated cells (* p < 0.05, ** p < 0.01)."
27738385
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"These results suggest that TRIM15 promotes, while CYLD inhibits, proliferation of melanoma cells."
34497368
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"Together, these results indicate that the increased expression of RIPK1 is responsible for induction of apoptosis in Mel-CV and ME1007 cells with CYLD silenced and that it does not play a role in the promotion of proliferation by CYLD silencing in ME4405 cells."
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"DISCUSSION As a tumor suppressor , CYLD inhibits cell proliferation in many cancer types including melanoma15 ."
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"In vitro cell proliferation was measured and the result shows that CYLD knockout causes cell proliferation enhancement and CYLD overexpression causes cell proliferation suppression (XREF_FIG C, D)."
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"MiR-501-5p upregulation corresponded with a downregulation of CYLD in the same tissues and cell lines, and overexpression of MiR-501-5p decreased CYLD expression, increased expression of cyclin D1 and c-myc and promoted the proliferation of hepatocellular carcinoma cells in vitro."
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"Full length CYLD but not CYLD C/S could significantly reduce proliferation rate of CYLD-/- MEFs after 72 hours (XREF_FIG) indicating that the deubiquitinating activity of CYLD is required for the observed phenotype."
21573132
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"CYLD inhibits proliferation and metastasis of melanoma cells in vivo."
19124656
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"Importantly, Vinc enhanced the expression of A20 and CYLD and inhibited the proliferation and survival of CML (K562) cells."
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"Functionally, CYLD inhibits cell proliferation and tumorigenesis through p18 in vivo."
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"Cyld inhibits tumor cell proliferation by blocking Bcl3-dependent NFkB signaling."
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"CYLD inhibits melanoma cell proliferation and migration."
22832488
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"Furthermore , as mentioned above , low CYLD expression may promote cell proliferation and accelerate recovery ."
33031450
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"Cyld inhibits tumor cell proliferation by blocking Bcl3 dependent NFkB signaling."
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"Depleting CYLD in TRIM15-knockdown A375 cells also restored ERK1 activity and proliferation (Fig. 7e,f and Extended Data Fig. 8d)."
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"Loss of CYLD stimulates cellular proliferation, migration, and invasion by triggering BCL-3 nucleus translocation and activation of cyclin D1 and N-cadherin [XREF_BIBR]."
| PMC
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"To determine whether CYLD inhibits cell proliferation and survival by suppressing activation of Akt, we performed cell proliferation and apoptosis assays on control and CYLD-knockdown prostate cancer cells treated with or without the PI3K inhibitors LY294002 or wortmannin."
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"These clinical findings support a link between the known tumor promoter Snail1 and its transcriptional target CYLD, indicating an important role for Snail1 to suppress CYLD during progression of melanoma and for CYLD to suppress melanoma cell proliferation and invasion."
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"Previous studies have also revealed that CYLD suppression leads to decreased apoptosis and increased proliferation by activating NF-κB [23, 65]."
30285829
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"Inhibition of GLI1 restored the CYLD expression mediated Snail signaling pathway, and caused a significant delay in the G1 to S phase transition, as well as proliferation."
21577203
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"CYLD prevents nuclear accumulation of BCL-3 and hence reduces Cyclin D1 expression and proliferation of keratinocytes."
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"A previous study reported that CYLD inhibits cell proliferation and apoptosis resistance in triple negative breast cancer."
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"These results suggest that CYLD inhibited SMC proliferation via blockade of the cyclin D1 and E2F pathway, possibly through deubiquitination of Bcl-3."
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"Interestingly, in melanoma cells, SNAIL has been shown to inhibit expression of CYLD, which in turn leads to increased melanoma proliferation and invasion [XREF_BIBR]."
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"Conversely, CYLD knockdown promotes cell proliferation and tumor growth of PCa [XREF_BIBR]."
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"However, a recent report indicated that the loss of CYLD in mouse keratinocytes enhances cell proliferation by increasing the nuclear activity of Bcl-30-associated NF-κB p50 and p52 subunits, rather than by increasing classical p65/p50 NF-κB action."
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"In contrast, CYLD silencing significantly promoted NPC cell proliferation relative to that observed in control cells (P < 0.001) (XREF_FIG)."
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"CYLD overexpression strongly suppressed the growth, proliferation, metastasis, and migration of NPC cells [135]."
32872147
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"Rescue of CYLD expression in melanoma cells reduced proliferation and invasion in vitro and tumor growth and metastasis in vivo."
19124656
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"These results indicated that CYLD overexpression and miR-197-3p suppression may inhibit cell proliferation and enhance apoptosis; therefore, CYLD overexpression may rescue the effects of miR-197-3p on cell function."
29286108
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"Previous research suggested that BTKis ibrutinib can largely increase CYLD miRNA transcription, which means increasing CYLD activity, could inhibit cells proliferation in CLL [XREF_BIBR]."
33827598
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"Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling."
16713561
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"miR-186 suppressed CYLD expression and promoted cell proliferation in human melanoma."
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"19 Loss of CYLD promotes the tumor cell proliferation because of enhanced expression of cyclin D1."
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"CYLD suppression enhanced proliferation, reduced apoptosis, and increased cell division of RA-FLSs and aggravated the activity of NF-kappaB in RA-FLSs."
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"We then determined the molecular function of CYLD in NPC cells, finding that CYLD inhibited NPC cell proliferation but promoted apoptosis according to CYLD-overexpression and -silencing analyses, respectively."
33149672
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"We found that CYLD levels were significantly decreased in both NPC tissues and cell lines, and that CYLD overexpression inhibited NPC cell proliferation and promoted apoptosis."
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"Results showed that overexpression of CYLD in HK1-EBV and HONE1-EBV cells inhibits cell proliferation."
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"TBK1-K38A expression blocked CYLD phosphorylation and inhibited the proliferation of MT4 cells."
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"71 The gene CYLD is mutated in familial cylindromatosis, an autosomal dominant disease characterized by benign tumors derived from cells of skin appendages 72 and thus it can be considered as a TS, CYLD inhibits tumor cell proliferation by blocking BCL-3-dependent NF-kappaB signaling."
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"Ectopic expression of CYLD wild-type gene suppressed C666-1 cell proliferation (XREF_FIG) and anchorage independent growth on soft agar (XREF_FIG), while expression of patient derived CYLD point and truncating mutations resulted in the loss of these tumour-suppressive activities (XREF_FIG)."
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"In addition, CYLD knockdown promoted the proliferation of HK1 and HONE1 cells, and restoration of p18 completely reversed the effect of CYLD depletion."
33654169
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"Functional assays revealed CYLD inhibits NPC cell proliferation and migration in vitro and suppresses NPC tumorigenicity and metastasis in vivo by negatively regulating the NF-kB signaling pathway."
32708712
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"CYLD also inhibited inflammation and proliferation in vascular cells and represented a novel target for the treatment or prevention of atherosclerosis [XREF_BIBR]."
27738385
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"Strikingly, although short hairpin RNA (shRNA) knockdown of CYLD promoted, as anticipated, cell proliferation in some melanoma cell lines, it reduced cell viability in a fraction of melanoma cell lines with relatively high levels of CYLD expression and did not impinge on survival and proliferation in a third type of melanoma cell lines."
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"Compared with the control group, miR-181 silencing or CYLD overexpression significantly attenuated cell proliferation, invasion and migration, and notably increased the proportion of apoptotic cells."
32901872
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"For instance, deubiquitinating enzyme, CYLD (Cylindromatosis tumor suppressor gene) is believed to suppress cell proliferation and tumorigenesis by removing K63 linked ubiquitin chains from TRAF2 and IKKgamma thereby inhibiting NF-kappaB activation XREF_BIBR."
22876279
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"Functionally , CYLD inhibits cell proliferation and tumorigenesis through p18 in vivo ."
33654169
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"As a result, loss of CYLD enhances basal ubiquitination, membrane recruitment and activation of Akt, thereby promoting cell proliferation, cell survival and glucose uptake, which are all important pro tumorigenic events."
23300340
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"CYLD Overexpression Inhibits NPC Cell Proliferation."
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"Strikingly, although shRNA knockdown of CYLD promoted, as anticipated, cell proliferation in some melanoma cell lines, it reduced cell viability in a fraction of melanoma cell lines with relatively high levels of CYLD expression and did not impinge on survival and proliferation in a third type of melanoma cell lines."
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"CYLD, a tumor suppresser gene, negatively regulates cell proliferation via a significant delay in the G1-S transition [XREF_BIBR]."
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"Loss of CYLD stimulates cellular proliferation , migration , and invasion by triggering BCL-3 nucleus translocation and activation of cyclin D1 and N-cadherin [ 99 ] ."
| PMC
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"In various tumor types, CYLD loss can lead to cell survival or cell proliferation."
20347313
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"Moreover, an increase in CYLD levels reduces the proliferation rate of MEF cells."
21573132
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"In the present study, we found that CYLD inhibition distinctly enhanced proliferation, reduced apoptosis, and increased the cell division of RA-FLSs and aggravated the activity of NF-κB in these cells, suggesting that CYLD is involved in RA-FLS hyperproliferation in RA."
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"In conclusion, these data demonstrate that the deubiquitinating enzyme CYLD may inhibit inflammation and proliferation in vascular cells and may represent a novel target for the treatment or prevention of atherosclerosis."
18245814
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"Overexpression of wild-type CYLD in HCC cell lines prevented cell proliferation, without affecting apoptosis, adhesion and migration."
24104553
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"Loss of CYLD in different types of tumors leads to either cell survival or proliferation."
21573132
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"These results suggest that loss of CYLD mediates proliferation and not survival in MEF cells."
21573132
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"Studies found that miR-362-5p reduces the expression of tumor suppressor protein CYLD, which leads to activate the NF-kB pathway to promote the proliferation, migration, and invasion of hepatocellular carcinoma cells and human breast cancer cells (Ni et al., 2015; Ni et al., 2016)."
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"Knockdown of CYLD expression reversed the cell proliferation promotion by miR-1288-in in GBM."
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"Of note, while silencing of CYLD promoted proliferation of melanocytes (XREF_FIG), overexpression of CYLD did not have any significant effect on melanocyte growth (XREF_FIG)."
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"Indeed, our results showed that the increase in ME4405 cell proliferation caused by CYLD knockdown was associated with upregulation of cyclin D1."
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"As a tumor suppressor, CYLD inhibits cell proliferation in many cancer types including melanoma XREF_BIBR."
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"Expression of CYLD inhibited cell proliferation in monolayer cell culture and reduced the capacity of anchorage independent growth as assessed by soft agar colony formation (XREF_FIG)."
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"Expression of CYLD inhibited cell proliferation in monolayer cell culture and reduced the capacity of anchorage-independent growth as assessed by soft agar colony formation ( xref )."
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"Exogenous expression of CYLD but not its catalytically deficient mutant markedly inhibited melanoma cell proliferation and migration in vitro and subcutaneous tumor growth in vivo."
22832488
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"In this study, we demonstrated that CYLD expression is downregulated in NPC tissues, and that CYLD overexpression inhibits NPC cell proliferation and promotes apoptosis, whereas CYLD knockdown reverses these effects in NPC cells."
33149672
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"These results suggest that CYLD inhibited SMC proliferation via blockade of the cyclin D1 and E2F pathway, possibly through deubiquitination of Bcl-3."
18245814
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"CYLD knockdown enhanced RA-FLS proliferation."
30285829
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"Functional assays revealed that CYLD represses MM cell proliferation and survival."
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