IndraLab

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"Studies found that miR-362-5p reduces the expression of tumor suppressor protein CYLD, which leads to activate the NF-kB pathway to promote the proliferation, migration, and invasion of hepatocellular carcinoma cells and human breast cancer cells (Ni et al., 2015; Ni et al., 2016)."
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"Knockdown of CYLD expression reversed the cell proliferation promotion by miR-1288-in in GBM."
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"Loss of CYLD stimulates cellular proliferation , migration , and invasion by triggering BCL-3 nucleus translocation and activation of cyclin D1 and N-cadherin [ 99 ] ."
| PMC
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"We found that CYLD levels were significantly decreased in both NPC tissues and cell lines, and that CYLD overexpression inhibited NPC cell proliferation and promoted apoptosis."
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"In this study, we demonstrated that CYLD expression is downregulated in NPC tissues, and that CYLD overexpression inhibits NPC cell proliferation and promotes apoptosis, whereas CYLD knockdown reverses these effects in NPC cells."
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"Functional assays revealed CYLD inhibits NPC cell proliferation and migration in vitro and suppresses NPC tumorigenicity and metastasis in vivo by negatively regulating the NF-kB signaling pathway."
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"CYLD Overexpression Inhibits NPC Cell Proliferation."
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"In contrast, CYLD silencing significantly promoted NPC cell proliferation relative to that observed in control cells (P < 0.001) (XREF_FIG)."
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"In vitro cell proliferation was measured and the result shows that CYLD knockout causes cell proliferation enhancement and CYLD overexpression causes cell proliferation suppression (XREF_FIG C, D)."
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"Overexpression of wild-type CYLD in HCC cell lines prevented cell proliferation, without affecting apoptosis, adhesion and migration."
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"Rescue of CYLD expression in melanoma cells reduced proliferation and invasion in vitro and tumor growth and metastasis in vivo."
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"CYLD also inhibited inflammation and proliferation in vascular cells and represented a novel target for the treatment or prevention of atherosclerosis [XREF_BIBR]."
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"MiR-501-5p upregulation corresponded with a downregulation of CYLD in the same tissues and cell lines, and overexpression of MiR-501-5p decreased CYLD expression, increased expression of cyclin D1 and c-myc and promoted the proliferation of hepatocellular carcinoma cells in vitro."
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"We then determined the molecular function of CYLD in NPC cells, finding that CYLD inhibited NPC cell proliferation but promoted apoptosis according to CYLD-overexpression and -silencing analyses, respectively."
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"A previous study reported that CYLD inhibits cell proliferation and apoptosis resistance in triple negative breast cancer."
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"CYLD prevents nuclear accumulation of BCL-3 and hence reduces Cyclin D1 expression and proliferation of keratinocytes."
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"CYLD inhibits proliferation and metastasis of melanoma cells in vivo."
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"In addition, studies have shown that the low expression of CYLD with a mutation number of 3 is related to disease development from monoclonal gammopathy of undetermined significance to MM, and the functional detection results indicated that the expression of CYLD suppresses the cell proliferation and survival of MM disease (26)."
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"Furthermore , as mentioned above , low CYLD expression may promote cell proliferation and accelerate recovery ."
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"Functionally, CYLD inhibits cell proliferation and tumorigenesis through p18 in vivo."
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"Results showed that overexpression of CYLD in HK1-EBV and HONE1-EBV cells inhibits cell proliferation."
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"These clinical findings support a link between the known tumor promoter Snail1 and its transcriptional target CYLD, indicating an important role for Snail1 to suppress CYLD during progression of melanoma and for CYLD to suppress melanoma cell proliferation and invasion."
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"In addition, CYLD knockdown promoted the proliferation of HK1 and HONE1 cells, and restoration of p18 completely reversed the effect of CYLD depletion."
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"Additionally, the increased levels of Snail1 in melanoma result in the reduced expression of the tumor suppressor cylindromatosis (CYLD), which is known to inhibit proliferation and metastasis [42] ."
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"Inhibition of GLI1 restored the CYLD expression mediated Snail signaling pathway, and caused a significant delay in the G1 to S phase transition, as well as proliferation."
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"Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NFkappaB signaling."
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"Loss of CYLD in different types of tumors leads to either cell survival or proliferation."
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"Full length CYLD but not CYLD C/S could significantly reduce proliferation rate of CYLD-/- MEFs after 72 hours (XREF_FIG) indicating that the deubiquitinating activity of CYLD is required for the observed phenotype."
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"These results suggest that loss of CYLD mediates proliferation and not survival in MEF cells."
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"71 The gene CYLD is mutated in familial cylindromatosis, an autosomal dominant disease characterized by benign tumors derived from cells of skin appendages 72 and thus it can be considered as a TS, CYLD inhibits tumor cell proliferation by blocking BCL-3-dependent NF-kappaB signaling."
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"Moreover, an increase in CYLD levels reduces the proliferation rate of MEF cells."
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"DISCUSSION As a tumor suppressor , CYLD inhibits cell proliferation in many cancer types including melanoma15 ."
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"We confirmed that CYLD suppressed NPC cell growth and proliferation, as evidenced by decreased CCK-8 OD value and EDU-positive ratio, indicating that CYLD functioned as a tumor suppressor ( Supplement[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"19 Loss of CYLD promotes the tumor cell proliferation because of enhanced expression of cyclin D1."
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"In line with this, the loss of CYLD promotes Akt hyperubiquitination and activation, as well as cell proliferation, survival and prostate tumorigenesis [120]."
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"These results suggest that CYLD inhibited SMC proliferation via blockade of the cyclin D1 and E2F pathway, possibly through deubiquitination of Bcl-3."
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"Cyld inhibits tumor cell proliferation by blocking Bcl3-dependent NFkB signaling."
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"To determine whether CYLD inhibits cell proliferation and survival by suppressing activation of Akt, we performed cell proliferation and apoptosis assays on control and CYLD-knockdown prostate cancer cells treated with or without the PI3K inhibitors LY294002 or wortmannin."
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"Conversely, CYLD knockdown promotes cell proliferation and tumor growth of PCa [XREF_BIBR]."
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"Functionally , CYLD inhibits cell proliferation and tumorigenesis through p18 in vivo ."
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"miR-186 suppressed CYLD expression and promoted cell proliferation in human melanoma."
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"As we expected, the MTT assay results showed that overexpression of CYLD obviously decreased the proliferation of A549 cells or H460 cells compared with that of untreated cells (* p < 0.05, ** p < 0.01)."
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"Subsequent studies have indicated that CYLD negatively regulates NF-κB signaling, tumor cell proliferation, and T cell development [9,10] ."
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"These results suggest that CYLD inhibited SMC proliferation via blockade of the cyclin D1 and E2F pathway, possibly through deubiquitination of Bcl-3."
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"Strikingly, although short hairpin RNA (shRNA) knockdown of CYLD promoted, as anticipated, cell proliferation in some melanoma cell lines, it reduced cell viability in a fraction of melanoma cell lines with relatively high levels of CYLD expression and did not impinge on survival and proliferation in a third type of melanoma cell lines."
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"Ectopic expression of CYLD wild-type gene suppressed C666-1 cell proliferation (XREF_FIG) and anchorage independent growth on soft agar (XREF_FIG), while expression of patient derived CYLD point and truncating mutations resulted in the loss of these tumour-suppressive activities (XREF_FIG)."
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"Compared with the control group, miR-181 silencing or CYLD overexpression significantly attenuated cell proliferation, invasion and migration, and notably increased the proportion of apoptotic cells."
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"Of note, while silencing of CYLD promoted proliferation of melanocytes (XREF_FIG), overexpression of CYLD did not have any significant effect on melanocyte growth (XREF_FIG)."
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"Together, these results indicate that the increased expression of RIPK1 is responsible for induction of apoptosis in Mel-CV and ME1007 cells with CYLD silenced and that it does not play a role in the promotion of proliferation by CYLD silencing in ME4405 cells."
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"Exogenous expression of CYLD but not its catalytically deficient mutant markedly inhibited melanoma cell proliferation and migration in vitro and subcutaneous tumor growth in vivo."
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"Interestingly, in melanoma cells, SNAIL has been shown to inhibit expression of CYLD, which in turn leads to increased melanoma proliferation and invasion [XREF_BIBR]."
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"As a tumor suppressor, CYLD inhibits cell proliferation in many cancer types including melanoma XREF_BIBR."
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"Indeed, our results showed that the increase in ME4405 cell proliferation caused by CYLD knockdown was associated with upregulation of cyclin D1."
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"As a result, loss of CYLD enhances basal ubiquitination, membrane recruitment and activation of Akt, thereby promoting cell proliferation, cell survival and glucose uptake, which are all important pro tumorigenic events."
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"Loss of CYLD stimulates cellular proliferation, migration, and invasion by triggering BCL-3 nucleus translocation and activation of cyclin D1 and N-cadherin [XREF_BIBR]."
| PMC
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"Interestingly, CYLD deficiency has been shown to promote PCa cell proliferation, cell survival, and tumorigenesis, and CYLD abundance is reduced in advanced-stage PCa samples, suggesting that CYLD may play a tumour-suppressive role in PCa [13]."
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"CYLD knockdown enhanced RA-FLS proliferation."
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"Depleting CYLD in TRIM15-knockdown A375 cells also restored ERK1 activity and proliferation (Fig. 7e,f and Extended Data Fig. 8d)."
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"CYLD inhibits melanoma cell proliferation and migration."
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"CYLD, a tumor suppresser gene, negatively regulates cell proliferation via a significant delay in the G1-S transition [XREF_BIBR]."
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"Expression of CYLD inhibited cell proliferation in monolayer cell culture and reduced the capacity of anchorage independent growth as assessed by soft agar colony formation (XREF_FIG)."
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"Expression of CYLD inhibited cell proliferation in monolayer cell culture and reduced the capacity of anchorage-independent growth as assessed by soft agar colony formation ( xref )."
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"Previous research suggested that BTKis ibrutinib can largely increase CYLD miRNA transcription, which means increasing CYLD activity, could inhibit cells proliferation in CLL [XREF_BIBR]."
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"These data suggest that loss of CYLD can promote basal cell proliferation and validate the functional significance of CYLD loss as seen in case 2.Prostatic BCCs are rare tumors of the prostate that, a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, a recent report indicated that the loss of CYLD in mouse keratinocytes enhances cell proliferation by increasing the nuclear activity of Bcl-30-associated NF-κB p50 and p52 subunits, rather than by increasing classical p65/p50 NF-κB action."
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"Furthermore, Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling."
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"[77] R. Massoumi, K. Chmielarska, K. Hennecke, A. Pfeifer, and R. Fassler, Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling."
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"Previous studies have also revealed that CYLD suppression leads to decreased apoptosis and increased proliferation by activating NF-κB [23, 65]."
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"In the present study, we found that CYLD inhibition distinctly enhanced proliferation, reduced apoptosis, and increased the cell division of RA-FLSs and aggravated the activity of NF-κB in these cells, suggesting that CYLD is involved in RA-FLS hyperproliferation in RA."
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"These results indicated that CYLD overexpression and miR-197-3p suppression may inhibit cell proliferation and enhance apoptosis; therefore, CYLD overexpression may rescue the effects of miR-197-3p on cell function."
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"CYLD overexpression strongly suppressed the growth, proliferation, metastasis, and migration of NPC cells [135]."
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"Cyld inhibits tumor cell proliferation by blocking Bcl3 dependent NFkB signaling."
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"Moreover, we discovered that CYLD inhibited tumor cell proliferation and enhanced the sensitivity to cell ferroptosis in PCa in vitro and in vivo, respectively."
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"TBK1-K38A expression blocked CYLD phosphorylation and inhibited the proliferation of MT4 cells."
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"Functional assays revealed that CYLD represses MM cell proliferation and survival."
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"Importantly, Vinc enhanced the expression of A20 and CYLD and inhibited the proliferation and survival of CML (K562) cells."
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"Also, based on in vitro and in vivo experiments, we proved that CYLD could suppress cell proliferation and enhance the sensitivity to cell ferroptosis via YAP/ACSL4 pathway."
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"For instance, deubiquitinating enzyme, CYLD (Cylindromatosis tumor suppressor gene) is believed to suppress cell proliferation and tumorigenesis by removing K63 linked ubiquitin chains from TRAF2 and IKKgamma thereby inhibiting NF-kappaB activation XREF_BIBR."
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"CYLD suppressed PCa cell proliferation in vitro and in vivo."
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"To be the contrary, CYLD over-expression in 22RV1 or PC-3 cells significantly decreased the cell proliferation in vitro and tumorigenesis in vivo (Fig. 2G, H and supplemental Fig. 2A, B)."
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"We found in Supplementary Figure 6A–C that CYLD over-expression suppressed cell proliferation and cell migration and invasion, whereas promoted apoptosis in SiHa cells."
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