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Statements
SCN5A inhibits pyraclofos. 3 / 3
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reach
"In addition, electrophysiological experiments using the heterologous expression system have shown that the voltage dependence of Nav1.5 is shifted in the hyperpolarized direction compared to that of Nav1.4; Nav1.5 activates at a lower voltage than Nav1.4 (Sheets and Hanck, 1999; Vilin et al., 2012)."
reach
"However, the mechanism of NaV1.5 mechanosensitivity remains unclear, which limits our ability to understand the contributions of NaV1.5 mutations to pathophysiology.Previous work showed that disease associated NaV1.5 mutations can disrupt voltage gating, andCONTACT Arthur Beyder beyder.arthur@mayo.edu Supplemental data for this article can be accessed here."
reach
"Mutations in the Na v 1.5-encoding SCN5A gene account for> 75% of BrS genotype positive cases, although the yield of SCN5A testing for clinical cases is only = ~ 25% to 30%.5 In the presence of the previously described changes in ion currents, particularly I Na reduction, the net repolarizing effect of I to during phase 1 is significantly enhanced, thus reducing cell voltage to values below those required to activate L-type Ca ++ channels."