IndraLab

Statements

KCNA3 binds DLG4. 8 / 13
2 2 | 1 7
sparser
"In T-lymphocytes, PSD-95 interacts with Kv1.3, inducing clustering and recruiting Kv1.3 into the IS xref ."
28186199
sparser
"For example, PSD-95 interacts with Kv1.3 and favors its polarization toward the IS ( xref ), whereas the negative regulatory subunit KCNE4 interacts with Kv1.3 and retains the channel in the ER, impairing the channel targeting to the IS and therefore causing a reduction in T cell proliferation and IL-2 production ( xref )."
37596785
sparser
"Therefore, a functional Kv1.3-PSD-95 interaction is required not only for correct Kv1.3 redistribution in the vicinity of IS formation but also to prevent a massive internalization of the channel as a consequence of PKC-dependent immunosuppressive insults."
28186199
sparser
"Through patch-clamp electrophysiology, immunochemistry, and co-immunoprecipitation, we found that while Kv1.3 and PSD-95 alone interact via the canonical C-terminal PDZ recognition motif of the channel, this molecular site of interaction acts to cluster the channels but the PSD-95 SH(3)-guanylate kinase domain functionally modulates Kv1.3 activity via two proline-rich domains in its N- and C-terminal."
17854350
sparser
"In those cells, Dlg family members interacted with Kv1.3 channel protein and recruited Kv1.3 channel protein into the immunological synapse, protecting Kv1.3 channel protein from degradation."
31028120
reach
"In summary, PSD-95 binds to Src-family kinases and Kv1.3, favoring the phosphorylation of the channel [78]."
37345053
sparser
"PSD-95 associated with Kv1.3 in HEK-293 cells ( xref ), affecting the channel membrane distribution ( xref )."
28186199
sparser
"Kv1.3 interacts with PSD-95 through a C-terminal PDZ-binding domain, defined by the last three residues of the channel (Thr 523 -Asp 524 -Val 525 ) xref ."
28186199