IndraLab

Statements

DLG4 binds KCNA3. 10 / 11
2 2 | 6
biogrid
No evidence text available
17854350
sparser
"Kv1.3 interacts with PSD-95 through a C-terminal PDZ-binding domain, defined by the last three residues of the channel (Thr 523 -Asp 524 -Val 525 ) xref ."
28186199
sparser
"PSD-95 associated with Kv1.3 in HEK-293 cells ( xref ), affecting the channel membrane distribution ( xref )."
28186199
sparser
"Therefore, a functional Kv1.3-PSD-95 interaction is required not only for correct Kv1.3 redistribution in the vicinity of IS formation but also to prevent a massive internalization of the channel as a consequence of PKC-dependent immunosuppressive insults."
28186199
sparser
"In T-lymphocytes, PSD-95 interacts with Kv1.3, inducing clustering and recruiting Kv1.3 into the IS xref ."
28186199
hprd
No evidence text available
12435606
sparser
"Through patch-clamp electrophysiology, immunochemistry, and co-immunoprecipitation, we found that while Kv1.3 and PSD-95 alone interact via the canonical C-terminal PDZ recognition motif of the channel, this molecular site of interaction acts to cluster the channels but the PSD-95 SH(3)-guanylate kinase domain functionally modulates Kv1.3 activity via two proline-rich domains in its N- and C-terminal."
17854350
hprd
No evidence text available
8938729
biogrid
No evidence text available
21726550
sparser
"In those cells, Dlg family members interacted with Kv1.3 channel protein and recruited Kv1.3 channel protein into the immunological synapse, protecting Kv1.3 channel protein from degradation."
31028120