IndraLab

Statements

ISG15 inhibits USP18. 17 / 17
| 17
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"Recently, human ISG15 deficiency was found to cause a decrease in USP18 accumulation and this was hypothesized to cause the loss of negative feedback of type I interferon signaling in these patients leading to auto-inflammation [XREF_BIBR]."
26555296
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"We further show that an absence of intracellular ISG15 in the patients ' cells prevents the accumulation of USP18 XREF_BIBR, XREF_BIBR, a potent negative regulator of IFN-alpha and beta signalling, resulting in the enhancement and amplification of IFN-alpha and beta responses."
25307056
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"By preventing USP18 degradation ISG15 stabilizes the interaction between IFNAR2 and USP18 (FIG."
32492472
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"Overexpressed ISG15 can lead to nonspecific conjugation, while in parallel, excess unconjugated ISG15 can suppress IFN-signaling by stabilizing USP18, a known inhibitor of the IFN pathway [57]."
35764457
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"We therefore analysed the impact of ISG15 on SKP2 mediated USP18 degradation."
25307056
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"In subsequent studies, engineered repression of USP18/UBP43 (ISG15 deconjugating enzyme) was shown to destabilize PML-RARα, reduce proliferation, and increase apoptosis in acute promyelocytic leukemia and lung cancer cell lines [169,170,171]."
35159348
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"Decreasing ISGylation by knockdown of the ISG15 E1 enzyme, Ube1L, in primary USP18(+/+) and USP18(−/−) hepatocytes led to increased MHV-3 replication."
24648452
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"ISG15 prevents degradation of IFNAR’s negative regulator USP18, and as a result, type I IFN signaling is strongly enhanced in the absence of ISG15 (119, 120)."
26958928
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"On the other hand, ISG15 can attenuate type I IFN signaling via USP18 stabilization."
38932312
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"ISG15 is known to promote USP18-mediated inhibition of type I 437 IFN signaling by stabilizing USP18 activity and preventing its proteasomal degradation(Zhang et 438 al., 2015), underscoring the role of ISG15 as a negative regulator of type I IFN responses when 439 co-upregulated with USP18."
| DOI
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"The authors also showed that intracellular ISG15 deficiency prevented ubiquitin specific peptidase 18 (USP18) accumulation."
30075154
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"It was further shown by the same group that the absence of intracellular ISG15 prevents the accumulation of USP18 thereby sustaining the effect of IFN-α/β inflammation (105, 117)."
36438941
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"This lack of intracellular free ISG15 prevents the accumulation of USP18, a known negative regulator of IFN-alpha and beta, resulting in enhanced IFN-alpha and beta immunity and autoinflammation, resembling Aicardi-Goutieres syndrome and spondyloenchondromatosis [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25453225
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"However, by de-conjugating ISG15, the virus also creates free ISG15, which in turn may affect the immune response in two opposite pathways: free ISG15 negatively regulates IFN signaling in humans by binding non-catalytically to USP18, yet at the same time free ISG15 can be secreted from the cell and induce the IFN pathway of the neighboring cells."
35764457
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"In turn, ISG15 prevents USP18 from being degraded by the proteasome."
35258551
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"In a follow-up report, Zhang et al. show that the absence of intracellular ISG15 in patients ' cells also prevents the accumulation of USP18, a potent negative regulator of type I IFN [XREF_BIBR]."
28087453
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"ISG15 can be associated with HERC5, IFIT1, PKR, and TRIM25 and enhance antiviral signaling by prolonging the state of signaling proteins such as IRF3 and STAT1 or can inhibit activation state by reversing the ISGylation via USP18 [72,73]."
38932231