IndraLab

Statements

AGTR1 binds OLR1. 16 / 16
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"Oxidized LDL but not angiotensin II induces cardiomyocyte hypertrophic responses through the interaction between LOX-1 and AT1 receptors."
34555408
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"As shown in the xref , we observed yellow puncta, indicating co-localization of AT1 and LOX-1 moving on the cell surface-focused image, with some of them disappearing after application of 10 μg/mL oxLDL, implying that the complex of LOX-1 and AT1 had been internalized."
33659870
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"Furthermore, through bimolecular fluorescence complementation analysis, we confirmed that ox-LDL rather than AngII stimulation induced the direct binding of LOX-1 and AT 1 -R. We conclude that direct binding of LOX-1 and AT1-R and the activation of downstream Gq protein are important mechanisms of ox-LDL-induced cardiomyocyte hypertrophy."
34555408
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"Our current findings strongly suggest that oxLDL triggers the activation of GRKs, followed by β-arrestin-induced clathrin-dependent endocytosis of the AT1-LOX-1 complex, whereby circulating oxLDL is translocated into vascular endothelial cells."
33659870
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"Similar red fluorescence intensity was observed in in situ PLA in non-permeabilized conditions in CHO-LOX-1-AT1, CHO-LOX-1-AT1mβ, and CHO-LOX-1-AT1mg, suggesting that these AT1 mutants interact with LOX-1, similar to the interaction with intact AT1 on the cellular surface ( xref D)."
33659870
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"Our current findings strongly suggest that oxLDL triggers the activation of GRKs, followed by beta-arrestin-induced clathrin dependent endocytosis of the AT1 and LOX-1 complex, whereby circulating oxLDL is translocated into vascular endothelial cells."
33659870
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"We previously found that the proximity between LOX-1 and AT1 on the cellular membrane was absent between LOX-1 and the Ang II type receptor (AT2), which is the isoform of AT1, in an in situ proximity ligation assay (PLA), indicating that LOX-1 specifically binds to AT1 ( xref )."
33659870
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"To investigate whether the activation of AT1 by oxLDL induced internalization of the LOX-1-AT1 complex, we utilized a live cell imaging technique using a real-time spinning disk confocal super-resolution microscope in CHO-K1 cells transiently transfected with LOX-1 labeled with mScarlet and AT1 labeled with eGFP."
33659870
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"Ox-LDL but not AngII could induce the binding of LOX-1 and AT1-R; inhibition of LOX-1 or AT1-R but not AngII could abolish the binding of these two receptors."
34555408
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"Chimeric analysis showed that oxLDL-induced AT1 signaling events are mediated via interactions between the intracellular domain of LOX-1 and AT1 that activate AT1."
25877213
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"However, since our findings imply that multiple molecules share the same LOX-1-AT1 system to exert their roles in atherogenesis, it is difficult to determine how these individual molecules utilize the system and, thus, contribute to disease progression."
33659870
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"Furthermore, through bimolecular fluorescence complementation analysis, we confirmed that ox-LDL rather than AngII stimulation induced the direct binding of LOX-1 and AT 1 -R. We conclude that direct binding of LOX-1 and AT1-R and the activation of downstream Gq protein are important mechanisms of ox-LDL-induced cardiomyocyte hypertrophy."
34555408
reach
"We previously found that the proximity between LOX-1 and AT1 on the cellular membrane was absent between LOX-1 and the Ang II type receptor (AT2), which is the isoform of AT1, in an in situ proximity ligation assay (PLA), indicating that LOX-1 specifically binds to AT1."
33659870
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"Therefore this cross-reactivity and interaction between LOX-1 and AT1 may also be contributing to other vasoreactivity, such as vascular responses to other vasoconstrictors, but this remains to be investigated."
32269313
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"Eight genes except OLR1 and AGTR1 were significantly associated with patients' grade."
32884943
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"To investigate whether the activation of AT1 by oxLDL induced internalization of the LOX-1 and AT1 complex, we utilized a live cell imaging technique using a real-time spinning disk confocal super-resolution microscope in CHO-K1 cells transiently transfected with LOX-1 labeled with mScarlet and AT1 labeled witheGFP."
33659870