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USP15 activates EIF4A1 protein stability. 2 / 2
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"Furthermore , a weak fluorescent signal of EIF4A1 was observed in the USP15 - / - mice , indicating that USP15 could also promote EIF4A1 protein stability in vivo ( Figure 5E ) ."
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"Moreover , we have observed EIF4A1 protein expression was significantly upregulated ( Figure 5D , 2nd panel ) while the RNA expression of EIF4A1 remain unchanged ( Supplementary Figure S6B ) which demonstrated that USP15 could interact with and deubiquitinate EIF4A1 , thus promoting EIF4A1 protein stability ."
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