IndraLab

Statements



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"The results indicated that USP1 knockdown significantly inhibited the proliferation of MHCC97H and SK‐Hep‐1 cells (Figure 10G)."

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"The numerous data demonstrate that inhibition of USP1 suppresses the proliferation and viability of malignant cells, sensitizes them to radiation and increases their sensitivity to various chemo- therapeutic agents, which opens up new opportunities for combined therapy of malignant neoplasms."

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"Similarly , pharmacological inhibition of USP1 by SJB3-019A significantly repressed cell proliferation and triggered B-ALL cell apoptosis ."

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"Conversely, ectopic USP1 expression in mesenchymal stem cells stabilized ID proteins, inhibited osteoblastic differentiation, and enhanced proliferation."

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"In addition, inhibition of USP1 decreased PC proliferation and promoted response to therapeutic agent enzalutamide in a KDM4A dependent manner."

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"USP1 knockdown inhibited cell proliferation by more than 2-fold within 72h of seeding and showed a simultaneous increase in caspase activity."

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"The supportive evidence is as follows : (i) USP1 knockdown decreased PC cell proliferation in vitro and tumorigenesis in vivo, and promoted the response to therapeutic agent enzalutamide; and (ii) inhibition of USP1 sensitized cancer cells to therapeutic agent enzalutamide, whereas this effect was blunted by overexpression of KDM4A."

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"USP1 overexpression enhanced the migration and invasion of CRC cells, while its silencing attenuated the cell vitality and proliferation, induced the apoptosis of CRC cells."

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"USP1 depletion abolished cellular proliferation and attenuated glycolytic metabolism."

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"Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells."

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"Notably , downregulation of USP1 could inhibit cell proliferation and promote apoptosis in a variety of solid tumors 9,11,12 ."

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"Consistent with increased p21, USP1 knockdown reduced U2-OS cell proliferation."

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"Recent studies have demonstrated that USP1 inhibition induced apoptosis and suppressed cell proliferation in acute myeloid leukemia ( AML ) and MM cells 12 , 13 ."

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"USP1 knockdown or ML-323 treatment decreases cell proliferation , and reduces expression of proliferating cell nuclear antigen ( PCNA ) , cyclin D1 and cyclin E1 ."

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"USP1 knockdown similarly reduced proliferation in HOS, SAOS, and SJSA, but not MG-63 osteosarcoma cells."

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"Similarly, pharmacological inhibition of USP1 by SJB3-019A significantly repressed cell proliferation and triggered B-ALL cell apoptosis."

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"Overexpression of USP1 promoted cell proliferation, apoptosis, migration and invasion, and decreased cell chemo-sensitivity; however, it could be partially reversed via the overexpression of miR-192-5p in osteosarcoma cell lines."