IndraLab

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"Therefore, USP1 promotes proliferation and PARPi resistance in BRCA1-deficient cancer cells."
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"USP1 knockdown inhibits their proliferation, migration, and invasion [17,18]."
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"For example, the ubiquitin-specific peptidase 1 (USP1) may promote proliferation and migration of HCC via controlling the protein stability of ribosomal protein S16 (RPS16) (Liao et al., 2021b)."
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"Inhibiting USP1 effectively suppresses tumor proliferation and migration and may help overcome resistance to cisplatin and PARP inhibitors."
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"In osteosarcoma cells, USP1 knockdown triggers osteogenic differentiation, whereas USP1 overexpression enhances proliferation, suggesting that, in this cell type, USP1 is involved in the maintenance of a stem cell state [106]."
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"A reduction in USP1 levels inhibits cancer cell proliferation, suppresses metastasis, and sensitizes cancer cells to irradiation and chemotherapeutic drugs in various cancers [17,18]."
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"However, the effect and molecular mechanisms of USP1 in bladder cancer have not been reported.We found that USP1 overexpression promoted the proliferation and migration of T24 bladder cancer cells."
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"USP1 Overexpression Promotes Cell Proliferation, Migration, and Invasion."
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"Similarly, pharmacological inhibition of USP1 by SJB3-019A significantly repressed cell proliferation and triggered B-ALL cell apoptosis."
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"The results showed that exogenous overexpression of USP1 increased cell proliferation and colony numbers, but overexpression of USP1 C90S did not have the same effects (Figure 2B,C)."
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"USP1 knockdown in TC71 (Fig. 3A, left) and MHH-ES1 (Fig. 3A, right) led to a dramatic reduction in the number of colonies formed in the absence of external stress stimuli, supporting a requisite role for USP1 in EWS cell growth and proliferation."
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"The results of the CCK-8 assay showed that USP1 deficiency significantly inhibited the proliferation of UMUC3 cells (Figure 3B), and the colony formation capacity of the USP1-deficient cells was lower than that of the wild-type cells (Figure 3C)."
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"Notably, we also observed a dramatic reduction in the number of spheroids formed in USP1 knockdown TC71 (Fig. 3B; Supplementary Fig. S2A, left) and MHH-ES1 (Fig. 3B; Supplementary Fig. S2A, right) cells compared with control, suggesting that USP1 promotes cancer stem/progenitor cell proliferation and self-renewal."
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"In cancer cells, USP1 contributes to enhanced cell proliferation and drug resistance by stabilizing proteins involved in tumorigenesis [32, 33]."
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"In summary, USP1 deficiency reduced the proliferation and migration of UMUC3 cells."
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"We observed that USP1 depletion or inhibition decreases cell proliferation (Fig. 3) with an increase in cell death by apoptosis (Fig. 4; Supplementary Fig. S3)."
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"The silencing or inhibition of USP1 expression inhibits cell proliferation in osteosarcoma, prostate cancer, and ovarian cancer [22,23,24], but USP1 does not affect the proliferation of tumor cells in liver, gastric, or breast cancers [25,26], indicating that its role differs in various tumors."
39513905
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"The phenotype results suggested that USP1 promoted cell proliferation, migration, and invasion."
39513905
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"USP1 promotes PDAC cell proliferation via BCAA catabolism."
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"USP1 overexpression enhanced cell proliferation in PDAC cells (Fig. S5B and C)."
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"Taken together, USP1 promotes PDAC cell proliferation via aiding BCAA catabolism."
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"USP1 depletion inhibited cell proliferation, epithelial-mesenchymal transition, and migration in PDAC cells."
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"In various types of cancer, USP1 is often overexpressed and mediates the stabilization of inhibitors of DNA binding and cell differentiation (ID proteins family) to regulate tumor proliferation, metastasis and apoptosis [29]."
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"USP1 depletion inhibits cell proliferation, migration, and tumor growth in vitro and in vivo."
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"USP1 promotes cell proliferation and migration in PDAC cell lines."
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"The Cell Counting Kit-8 (CCK8), colony formation, and 5-ethynyl-2′-deoxyuridine (EdU) assays showed that depletion of USP1 significantly inhibited cell proliferation in vitro (Figs."
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"We have found that USP1 enhanced malignant features of PDAC cells, including cell proliferation and migration."
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"USP1 silencing suppressed ESCC cell proliferation, invasion, and immune escape, which were reversed by CXCR4 overexpression."
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"In addition, USP1 can stabilize DNA binding inhibitor 1 (ID1) and promote cancer cell proliferation [18]."
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"In addition, inhibition of USP1 decreased PC proliferation and promoted response to therapeutic agent enzalutamide in a KDM4A dependent manner."
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"The CCK8 assay showed that USP1 depletion sharply inhibited hepatocellular carcinoma cell proliferation (Fig. 3C, D)."
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"Similarly , pharmacological inhibition of USP1 by SJB3-019A significantly repressed cell proliferation and triggered B-ALL cell apoptosis ."
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"To inquire whether TAZ is involved in USP1-mediated proliferation, migration, colony formation and apoptosis in hepatocellular carcinoma cells, we carried out several rescue experiments."
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"Notably , downregulation of USP1 could inhibit cell proliferation and promote apoptosis in a variety of solid tumors 9,11,12 ."
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"The supportive evidence is as follows : (i) USP1 knockdown decreased PC cell proliferation in vitro and tumorigenesis in vivo, and promoted the response to therapeutic agent enzalutamide; and (ii) inhibition of USP1 sensitized cancer cells to therapeutic agent enzalutamide, whereas this effect was blunted by overexpression of KDM4A."
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"Recent studies have demonstrated that USP1 inhibition induced apoptosis and suppressed cell proliferation in acute myeloid leukemia ( AML ) and MM cells 12 , 13 ."
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"The numerous data demonstrate that inhibition of USP1 suppresses the proliferation and viability of malignant cells, sensitizes them to radiation and increases their sensitivity to various chemo- therapeutic agents, which opens up new opportunities for combined therapy of malignant neoplasms."
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"USP1 knockdown inhibited cell proliferation by more than 2-fold within 72h of seeding and showed a simultaneous increase in caspase activity."
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"USP1 knockdown suppresses T-ALL cell proliferation in vitro and in vivo."
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"USP1 overexpression enhanced the migration and invasion of CRC cells, while its silencing attenuated the cell vitality and proliferation, induced the apoptosis of CRC cells."
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"USP1 promotes T-ALL cell glycolysis and proliferation by regulating PLK1-LDHA axis."
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"USP1 enhances the proliferation, invasion, and metastasis of CCA by stabilizing PARP1."
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"Conversely, upregulation of USP1 increased proliferation in RBE cells."
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"To assess whether USP1 contributes to glycolysis and proliferation of T-ALL cells through the regulation of PLK1-LDHA axis, we added PLK1 inhibitor BI2536 into Jurkat cells with forced expression of USP1."
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"As shown in Figure 5A-B, inhibiting PLK1 profoundly counteracted the USP1-mediated enhancement of proliferation and lactate production."
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"Collectively, these findings indicate that USP1 can promote CCA proliferation and metastasis primarily through PARP1 both in vitro and in vivo."
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"A fraction of primary human osteosarcomas were found to overexpress both USP1 and ID proteins, and ectopic USP1 expression in mesenchymal stem cells stabilized ID proteins, blocked differentiation, an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Collectively, these results emphasize a significant role of PLK1-LDHA axis in USP1-mediated promotion of T-ALL cell glycolysis and proliferation."
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"Pharmacological inhibition of USP1 suppresses the proliferation and glycolysis in T-ALL cells."
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"Ectopic expression of USP1 in mesenchymal stem cells inhibited osteoblastic differentiation, and enhanced cell proliferation through stabilizing ID (inhibitor of DNA binding) proteins [11]."
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"On the basis of the findings that USP1 depletion impeded the proliferation and glycolysis of T-ALL cells, we next assessed the effect of the USP1 inhibitor ML323 on cell viability in T-ALL cell lines."
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"Some recent studies have reported the oncogenic functions of USP1 in multiple cancers.9 USP1 deubiquitylates ID proteins to help maintain stem cell properties in osteosarcoma.12 Moreover, USP1 regulates the Fanconi anemia pathway by deubiquitinating FANCD2.10 11 15 Of note, USP1 also promotes cancer cell proliferation and drug resistance in cancers, including T-ALL.8 26 In this study, we found that USP1 knockdown decreased cell proliferation in vitro and in vivo."
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"USP1 could promote the proliferation of PCa cells, while the knockdown of the USP1 gene led to the inhibition of cellular proliferation (Liao et al., 2021a)."
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"Collectively, these results demonstrated that the knockdown of USP1 in vivo inhibited the proliferation of rituximab/chemotherapy resistant DLBCL cells."
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"Overexpression of MAX or MYC rescued the inhibition of cell proliferation induced by USP1 knockdown in cell and mouse models of rituximab/chemotherapy resistant DLBCL."
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"Through transcriptomic analysis, we uncover that the USP1–BRD4 axis promotes liver cancer cell proliferation through upregulating a group of cancer-related genes."
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"Overexpression of USP1 promoted cell proliferation, apoptosis, migration and invasion, and decreased cell chemo-sensitivity; however, it could be partially reversed via the overexpression of miR-192-5p in osteosarcoma cell lines."
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"Both inhibition of USP1 with shRNA knockdown and pimozide treatment inhibited cell proliferation and induced autophagy and cell cycle arrest in DLBCL cells.As a deubiquitylation enzyme, USP1 binds to the target proteins and maintains their stability by removing the ubiquitylation chain."
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"Having found USP1 promoted BRD4 protein stability in liver cancer cells, we next investigated whether the USP1–BRD4 axis promoted liver cancer cell proliferation."
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"To examine whether USP1 overexpression contributed to cell proliferation like BRD4, we knocked-down USP1 and performed both CCK8 and clonogenesis assays."
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"These data collectively showed USP1 promotes liver cancer cell proliferation partially through BRD4."
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"Ectopic expression of USP1 statistically enhanced cell proliferation, migration and invasion abilities and decreased cell apoptosis and chemo-sensitivity in 143B and U2OS cells."
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"Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells."
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"Furthermore, using a nude-mice xenograft tumor model, we noted that USP1 inhibition effectively suppressed tumor proliferation and increased the expression of NK cell-associated markers."
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"In breast cancer, the upregulation of USP1 expression and deubiquitination of KPNA promotes cell proliferation, migration, and invasion in vitro and promotes lung metastasis of breast cancer cells [13]."
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"Silencing of USP1 inhibited cell proliferation and invasion through reducing expression of some downstream proteins, including Notch signaling pathway."
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"Moreover, we also found that ectopic expression of USP1 promoted cell proliferation and migration, decreased cell chemo-sensitivity, which could be partially reversed by overexpression of miR-192-5p."
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"In U2OS cells (a human OS cell line), silencing USP1 attenuated U2OS proliferation and invasion 17."
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"Furthermore, inhibition of USP1 reduced PC proliferation and promoted resistance to enzalutamide in a KDM4A-dependent manner (50)."
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"USP1 knockdown or ML-323 treatment decreases cell proliferation , and reduces expression of proliferating cell nuclear antigen ( PCNA ) , cyclin D1 and cyclin E1 ."
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"To determine whether TAZ is involved in USP1-mediated proliferation, migration, and invasion properties of OS, we transfected Flag-labeled TAZ plasmids into 143B and HOS cells."
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"Inhibition of USP1 by ML323 suppressed proliferation, migration and invasion of OS cell lines."
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"Taken together, these findings revealed that inhibition of USP1 by ML323 inhibits proliferation, migration, and invasion in OS cell lines."
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"Silencing USP1 in U2OS cells (a human OS cell line) attenuated U2OS proliferation and invasion 17."
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"Knockdown of USP1 inhibited OV cellular proliferation."
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"Our results showed that USP1 inhibition by ML323 had the similar impact on Hippo signaling pathway and effectively suppressed the migration, proliferation, EMT, and metastasis of OS both in vitro and in vivo."
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"Functional studies showed that inhibition of USP1 blocked OV cell proliferation and cell cycle."
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"Consistent with increased p21, USP1 knockdown reduced U2-OS cell proliferation."
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"Similarly, knockdown of USP1 also inhibited the proliferation of ovarian cancer cells."
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"While the CD133 population of A673, EW8, and TC32 Ewing sarcoma cells displayed dose-dependent growth inhibition by chemotherapy, silencing of USP1 inhibited cell proliferation and made cells more resistant to chemotherapy (Figure 3A, 3B and Supplementary Figure 1A, 1B, 1E, 1F)."
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"Conversely, while the C133 population of A673, EW8, and TC32 cells was more resistant to chemotherapy, USP1 lentivirus infection of the CD133 population, which increased the USP1 levels comparable to those in the CD133 population, stimulated cell proliferation, and made cells more sensitive to chemotherapy (Figure 3C, 3D and Supplementary Figure 1C, 1D, 1G, 1H)."
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"Using these PDX tumor-derived cells, we found that USP1 silencing in the CD133 population inhibits cell proliferation and makes cells more resistant to chemotherapy (Figure 3E, 3F) and that USP1 lentivirus infection of the CD133 population stimulates cell proliferation and makes cells more sensitive to chemotherapy (Figure 3G, 3H)."
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"USP1 silencing in the CD133 population inhibited A673 cell proliferation (Figure 3B), which was rescued by a cdc42 inhibitor, ML141 (Figure 7A; untreated vs. ML141), suggesting that USP1 normally stimulates Ewing sarcoma growth through cdc42 inhibition."
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"For example, in breast cancer, USP1 regulates the stability of the TAZ protein through ubiquitination modification, and inhibition of USP1 can reduce the proliferation and migration of breast cancer cells [54]."
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"USP1 knockdown similarly reduced proliferation in HOS, SAOS, and SJSA, but not MG-63 osteosarcoma cells."
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"USP1 overexpression also enhanced NPC cell proliferation ( Fig. 8 D)."
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"The results indicated that USP1 knockdown significantly inhibited the proliferation of MHCC97H and SK‐Hep‐1 cells (Figure 10G)."
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"It was found that compared to cells transfected with S2739 alone, the USP1 OE group significantly promoted tumor cell proliferation, migration and invasion, but inhibited tumor cell apoptosis."
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