IndraLab

Statements

USP8 binds NS1. 3 / 3
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"One study found that ectopically expressed ZIKV NS1 interacts directly with host de-ubiquitinase USP8 to facilitate the deubiquitination of caspase-1, increasing its stability [ xref ]."
32937990
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"(ii) Ubiquitin-mediated negative effect on the host immune response leading to a positive effect on viral replication, e.g., Zika virus (ZIKV) NS1 interacts with USP8 (Ubiquitin Specific Peptidase 8) and causes the deubiquitination of Caspase 1 and prevents its proteasomal degradation."
33396899
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"Anti-viral PARP 13 PB2, PA (IAV) ADP ribosylation of the PB2, PA proteins promotes recognition by E3 ubiquitin ligase and subsequent degradation [41] Pro-viral PARP1 Type I Interferon Receptor (IFNAR1) ADP ribosylation by PARP1promotes proteasomal degradation of IFNAR1 during IAV infection [42] (ii) Ubiquitin-mediated negative effect on the host immune response leading to a positive effect on viral replication, e.g., Zika virus (ZIKV) NS1 interacts with USP8 (Ubiquitin Specific Peptidase 8) and causes the deubiquitination of Caspase 1 and prevents its proteasomal degradation."
33396899