IndraLab

Statements

USP8 inhibits EGFR. 7 / 9
| 7
reach
"In keeping with this intermediate phenotype, UBPY depletion partially reduced the interaction of EGFR with ESCRT-III."
23477725
reach
"By the same mechanism, USP8 also directs the trafficking and lysosomal degradation of CXCR4 [XREF_BIBR], MET and epidermal growth factor receptor [XREF_BIBR, XREF_BIBR], implying that its loss consequent to increased RNF41 abundance would prolong and potentially amplify invasion signaling by these receptors."
26231668
reach
"By removing the lysosomal sorting signal, UBPY negatively regulates the downregulation of EGFR [10]."
17720156
reach
"While one report suggests that Usp8 inhibits EGFR degradation [25], we and others have demonstrated that Usp8 promotes EGFR degradation [21,26]."
23333852
reach
"While some reports suggest that Usp8 inhibits EGFR degradation [40], we and others demonstrated that Usp8 stimulates EGFR degradation [41,42]."
21044682
reach
"USP8 has been shown to have opposing effects on EGF receptor degradation by either directly deubiquitinating receptors to prevent their degradation, or by deubiquitinating ESCRT complex proteins to stabilize them and thus promote EGF receptor degradation [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
23316392
reach
"Depletion of USP8 with siRNA inhibits EGFR activation and increases EGFR degradation [32], similar to the effect of depleting SEPW1, and suggests the possibility SEPW1 might regulate USP8."
25721765