IndraLab

Statements

USP8 inhibits EGFR. 12 / 14
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"Depletion of USP8 with siRNA inhibits EGFR activation and increases EGFR degradation [32], similar to the effect of depleting SEPW1, and suggests the possibility SEPW1 might regulate USP8."
25721765
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"By removing the lysosomal sorting signal, UBPY negatively regulates the downregulation of EGFR [10]."
17720156
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"USP8 has been shown to have opposing effects on EGF receptor degradation by either directly deubiquitinating receptors to prevent their degradation, or by deubiquitinating ESCRT complex proteins to stabilize them and thus promote EGF receptor degradation [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
23316392
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"In keeping with this intermediate phenotype, UBPY depletion partially reduced the interaction of EGFR with ESCRT-III."
23477725
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"Further knockdown of USP8 in Arl4A-depleted cells suppressed the accelerated EGFR degradation in Arl4A-depleted cells (Supplementary Fig. 18c)."
38030597
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"While one report suggests that Usp8 inhibits EGFR degradation [25], we and others have demonstrated that Usp8 promotes EGFR degradation [21,26]."
23333852
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"Importantly, both the accumulation of ubiquitin on endosomes and defective EGFR trafficking can be rescued by expression of siRNA-resistant USP8 [55] ."
17961905
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"By the same mechanism, USP8 also directs the trafficking and lysosomal degradation of CXCR4 [XREF_BIBR], MET and epidermal growth factor receptor [XREF_BIBR, XREF_BIBR], implying that its loss consequent to increased RNF41 abundance would prolong and potentially amplify invasion signaling by these receptors."
26231668
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"As a result, USP8 activity enhances the stability of EGFR (an essential regulator of proliferation and differentiation), whereas USP8 inhibition promotes EGFR down-regulation."
37190052
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"Mizuno et al. [38] , using a pSilencer short-hairpin construct, proposed that siRNA knockdown of UBPY enhanced the rate of EGFR downregulation and might therefore act in a similar fashion to that prop[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16996268
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"Importantly, both the accumulation of ubiquitin on endosomes and defective EGFR trafficking can be rescued by expression of siRNA-resistant UBPY [61] ."
16996268
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"While some reports suggest that Usp8 inhibits EGFR degradation [40], we and others demonstrated that Usp8 stimulates EGFR degradation [41,42]."
21044682