IndraLab

Statements

PKA activates KCNQ2. 3 / 3
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"Downstream genes, in turn, form 2 groups : 1) functionally activated ones that include transcription factors (like Nfatc2 that is functionally activated by PKA dependent glycogen synthase kinase-3beta inactivation) or any cellular function effectors (like Kcnq2 that is functionally activated by PKA dependent phosphorylation) and 2) transcriptionally activated, which also include transcription factors (like Per2) and molecules that participate in some cellular process (like Pon1)."
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"Application of either 8-Cl-AMPc (500 muM), an activator of PKA, or of the phorbol 12-myristate 13-acetate (PMA), an activator of PKC, did not produce variations of the KCNQ2 channel activity (data not[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The KCNQ2 isoform is sensitive to cAMP-PKA signaling, where KCNQ2 conductance is increased by PKA phosphorylation, leading to a reduction in neuronal firing."
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