IndraLab

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PKA activates KCNQ2. 6 / 6
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"The KCNQ2 isoform is sensitive to cAMP-PKA signaling, where KCNQ2 conductance is increased by PKA phosphorylation, leading to a reduction in neuronal firing."
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"Importantly, the open state of the KCNQ2 isoform, and its heteromer KCNQ2/KCNQ3, are increased by PKA phosphorylation."
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"Downstream genes, in turn, form 2 groups : 1) functionally activated ones that include transcription factors (like Nfatc2 that is functionally activated by PKA dependent glycogen synthase kinase-3beta inactivation) or any cellular function effectors (like Kcnq2 that is functionally activated by PKA dependent phosphorylation) and 2) transcriptionally activated, which also include transcription factors (like Per2) and molecules that participate in some cellular process (like Pon1)."
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"As PKA signaling increases the open probability of KCNQ2 channels, we next tested whether activating cAMP-PKA signaling with forskolin would increase KCNQ currents."
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"For instance, whereas PKA-mediated phosphorylation increases the currents in Kv7.1, Kv7.2, and Kv7.3—members of the KCNQ family—tyrosine phosphorylation of these channels downregulates their expression in neurons [10]."
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"Application of either 8-Cl-AMPc (500 muM), an activator of PKA, or of the phorbol 12-myristate 13-acetate (PMA), an activator of PKC, did not produce variations of the KCNQ2 channel activity (data not[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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