IndraLab

Statements

USP10 activates TP53. 28 / 33
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"Taken together, our findings disclose a novel mechanism that hypoxia-inducible circWSB1 could interact with USP10 to attenuate USP10 mediated p53 stabilization and promote the progression of BC, providing an alternative prognostic biomarker and therapeutic target for BC."
35351136
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"Upon DNA damage, USP10 deubiquitylates and activates p53."
27516771
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"Upon cellular stresses, such as DNA damage or oncogene activation, the TP53 degradation process is attenuated by USP7 and USP10, two deubiquitinating enzymes."
31695837
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"For example, USP7 regulates the stability of both p53 and Mdm2 and maintains p53 ubiquitination levels; 120 USP2 mediates the stability of Mdm2; 121 USP10 modulates p53 localization and stability; 122 OTUB1 abrogates p53 ubiquitination and activates p53."
32140262
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"USP10 modulates anterograde and retrograde vesicular trafficking, the localization and stability of p53 and binds Dengue virus RNA."
23141719
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"Previous report showed that USP10 positively regulate TP53."
31695837
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"In the case of DNA damage, USP10 is stabilized and translocates to the nucleus to activate and stabilize p53."
30319415
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"Wildtype TP53 is usually rescued from proteasomal degradation by USP10."
30107050
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"It will be interesting to discover whether overexpression of USP7 could also rescue the diminished DNA damage induced p53 response caused by USP10 depletion."
20144755
eidos
"After DNA damage , USP10 is stabilised , and a fraction of USP10 translocates to the nucleus to activate p53 ."
23712866
eidos
"In the case of DNA damage , USP10 is stabilized and translocates to the nucleus to activate and stabilize p53 ."
30319415
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"Since USP10 is known as a deubiquitinating protease of p53, inhibition of USP10 by spautin-1 may promote the degradation of p53."
21962518
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"The alanine mutation of the Thr 42 / Ser 337 has not been shown to interfere with the capability of USP10 to deubiquitinate p53, but it impedes its nucleolar translocation and stabilization, which in effect suppresses USP10 mediated activation of p53 in response to DNA damage [XREF_BIBR]."
21480003
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"Western blotting also showed that p53 was reduced dramatically by miR-138 overexpressing, along with the decreased USP10 level (Figure 1E)."
31695837
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"We identify 9 direct binding partners of p53 in the nuclear RNA interactome, including USP10, which deubiquitinates and activates p53 in response to DNA damage, and Sumo1, which can itself become covalently coupled to p53 to regulate its activity and subcellular localization (XREF_SUPPLEMENTARY) XREF_BIBR XREF_BIBR XREF_BIBR."
27040163
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"One reason is that it can activate the p53 pathway by increasing USP10 expression, but it is more toxic to the majority of cancer cell lines; it has not been approved by the Food and Drug Administration (FDA)."
35627217
eidos
"USP10 , upon ATM-dependent phosphorylation at threonine 42 and serine 337 residues , is stabilized and translocated to the nucleus to activate p53 through deubiquitinating activity , inducing tumor cell suppression [ 53 ] ."
| PMC
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"Overall, these results suggest that USP10 potentiates p53 function in cells."
20096447
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"By removing conjugated ubiquitin from target proteins, including p53, USP10 increases p53 stability in unstressed cells."
32075244
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"Thus , depletion of USP10 would cause a decrease in p53 levels and lead to cisplatin resistance ."
32382008
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"As shown in XREF_FIG, downregulation of USP10 increased cancer cell proliferation in p53 +/+ cells, while USP10 expression levels have no apparent effect on proliferation in cells lacking p53."
20096447
sparser
"Upon DNA damage, USP10 deubiquitylates and activates p53."
27516771
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"Under DNA damage, USP10 becomes stabilization and translocates to the nucleus to activate and stabilize nuclear p53."
31721429
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"Usp10 inhibition attenuated H 2 O 2 -induced senescence in MLO-Y4 cells, as indicated by p53 and p21 quantification, a senescence associated beta-galactosidase (SA-beta-gal) assay, and p53 localization visualization with a confocal microscope."
34223980
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"P53 stability was decreased in cells stably expressing USP10 shRNA; while reconstitution with shRNA resistant USP10 restored p53 stability (XREF_FIG)."
20096447
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"The USP10 responsible deubiquitination is able to stimulate the anti-oncogenic activity of p53 both in renal clear cell carcinoma [XREF_BIBR] and colorectal cancer [XREF_BIBR], highlighting the potential significance of USP10 and p53 targeted cancer treatment."
27681874
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"Indeed, USP10 depletion attenuates DNA damage induced stabilization of p53, an effect that was rescued by overexpression of wild-type USP10 but not by mutant USP10 lacking ATM phosphorylation sites."
20144755
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"Stable knockdown of USP10 by shRNA inhibited p21 promoter activity in HCT116 p53 +/+ cells, but had little effect in HCT116 p53 -/- cells (XREF_FIG)."
20096447