IndraLab

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USP10 activates TP53. 48 / 53
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"An early DNA damage response is ATM-mediated stabilization and the nuclear translocation of USP10, which, in turn, activates p53 [64]."
38672417
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"USP10-specific UbVs exhibited potent inhibitory activity against the enzyme, leading to destabilization of p53 and increased nuclear export of p53 to the cytoplasm, providing yet another strategy for modulation of the p53/MDM2 pathway [60]."
37626927
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"USP10 , upon ATM-dependent phosphorylation at threonine 42 and serine 337 residues , is stabilized and translocated to the nucleus to activate p53 through deubiquitinating activity , inducing tumor cell suppression [ 53 ] ."
| PMC
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"Functioning as a competing endogenous RNA (ceRNA) [33], lnc-NR3C binds competitively to microRNA-129-5p, thereby regulating USP10-triggered p53 activation."
38388775
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"Under DNA damage, USP10 becomes stabilization and translocates to the nucleus to activate and stabilize nuclear p53."
31721429
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"Thus , depletion of USP10 would cause a decrease in p53 levels and lead to cisplatin resistance ."
32382008
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"Hypoxic-induced circWSB1 can interact with ubiquitin-specific peptidase 10 (USP10) to reduce p53 stability mediated by USP10 and promote progression of breast cancer, making it a potential therapeutic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37328395
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"Upon DNA damage, USP10 deubiquitylates and activates p53."
27516771
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"Besides stabilizing p53 protein, USP10 can also mediate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) stabilization and further promote breast cancer metastasis [ 24 ]."
37328395
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"The USP10 responsible deubiquitination is able to stimulate the anti-oncogenic activity of p53 both in renal clear cell carcinoma [XREF_BIBR] and colorectal cancer [XREF_BIBR], highlighting the potential significance of USP10 and p53 targeted cancer treatment."
27681874
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"As shown in XREF_FIG, downregulation of USP10 increased cancer cell proliferation in p53 +/+ cells, while USP10 expression levels have no apparent effect on proliferation in cells lacking p53."
20096447
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"For example, USP7 regulates the stability of both p53 and Mdm2 and maintains p53 ubiquitination levels; 120 USP2 mediates the stability of Mdm2; 121 USP10 modulates p53 localization and stability; 122 OTUB1 abrogates p53 ubiquitination and activates p53."
32140262
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"Furthermore, our study demonstrates that lnc-NR3C, acting as a competing endogenous RNA (ceRNA), upregulates USP10 expression by sequestering miR-129-5p, thereby augmenting the stability of the p53 protein and promoting apoptosis."
38388775
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"Further analysis unraveled that HSPA12A acted as a scaffolding protein to bind p53 and ubiquitin specific protease 10 (USP10), thereby promoting the USP10-mediated p53 protein stability for glycolysis inhibition, which ultimately resulted in suppression of CF activation."
38219869
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"The genetic deletion or inhibition of USP10 was reported to inhibit the growth of lung cancer xenografts lacking wild-type p53 and enhance cisplatin sensitivity [32]."
36076996
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"In our study, we have newly uncovered a method to control p53 activity in human cells, where lnc-NR3C activates p53 signaling by increasing USP10 expression."
38388775
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"One reason is that it can activate the p53 pathway by increasing USP10 expression, but it is more toxic to the majority of cancer cell lines; it has not been approved by the Food and Drug Administration (FDA)."
35627217
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"Overall, these results suggest that USP10 potentiates p53 function in cells."
20096447
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"Usp10 inhibition attenuated H 2 O 2 -induced senescence in MLO-Y4 cells, as indicated by p53 and p21 quantification, a senescence associated beta-galactosidase (SA-beta-gal) assay, and p53 localization visualization with a confocal microscope."
34223980
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"An early DNA damage response is ATM-mediated stabilization and the nuclear translocation of USP10, which, in turn, activates p53 [ xref ]."
38672417
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"P53 stability was decreased in cells stably expressing USP10 shRNA; while reconstitution with shRNA resistant USP10 restored p53 stability (XREF_FIG)."
20096447
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"By removing conjugated ubiquitin from target proteins, including p53, USP10 increases p53 stability in unstressed cells."
32075244
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"For example, circRPN2 inhibits aerobic glycolysis and metastasis in HCC by accelerating enolase 1 (ENO1) degradation and regulating the miR-183-5p/FOXO1 axis and is a potential prognostic biomarker and therapeutic target for hepatocellular carcinoma [32]; circRIC8B acts as a sponge for miR-199b-5p, preventing it from reducing LPL mRNA level, which promotes altered lipid metabolism and facilitates the progression of chronic lymphocytic leukemia (CLL) [33]; and hypoxia-induced circWSB1 can interact with USP10 to attenuate USP10-mediated p53 stabilization and promote BC progression, providing an alternative breast cancer (BC) prognostic marker and therapeutic target for BC [34]."
38686459
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"For example, USP10 could enhance the proliferation and metastasis of NSCLC by stabilizing HDAC744, whereas USP10 can stabilize p53 and inhibit breast cancer progression 45."
37786443
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"In the case of DNA damage , USP10 is stabilized and translocates to the nucleus to activate and stabilize p53 ."
30319415
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"Taken together, our findings disclose a novel mechanism that hypoxia-inducible circWSB1 could interact with USP10 to attenuate USP10 mediated p53 stabilization and promote the progression of BC, providing an alternative prognostic biomarker and therapeutic target for BC."
35351136
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"Since USP10 is known as a deubiquitinating protease of p53, inhibition of USP10 by spautin-1 may promote the degradation of p53."
21962518
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"After DNA damage , USP10 is stabilised , and a fraction of USP10 translocates to the nucleus to activate p53 ."
23712866
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"We identify 9 direct binding partners of p53 in the nuclear RNA interactome, including USP10, which deubiquitinates and activates p53 in response to DNA damage, and Sumo1, which can itself become covalently coupled to p53 to regulate its activity and subcellular localization (XREF_SUPPLEMENTARY) XREF_BIBR XREF_BIBR XREF_BIBR."
27040163
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"In the case of DNA damage, USP10 is stabilized and translocates to the nucleus to activate and stabilize p53."
30319415
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"USP10 becomes stabilized after DNA damage by ATM-mediated phosphorylation, and is then able to enter the nucleus, where it contributes to further activate p53 [103] ."
24704338
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"Indeed, USP10 depletion attenuates DNA damage induced stabilization of p53, an effect that was rescued by overexpression of wild-type USP10 but not by mutant USP10 lacking ATM phosphorylation sites."
20144755
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"It will be interesting to discover whether overexpression of USP7 could also rescue the diminished DNA damage induced p53 response caused by USP10 depletion."
20144755
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"The present study has revealed that HSPA12A acted as an inhibitor of CF activation and MI-induced fibrosis by suppressing glycolysis via its ability to increase the USP10-mediated p53 protein stability (Fig. 6j)."
38219869
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"USP10 is stabilized after DNA damage and translocates to the nucleus to activate p53."
25444757
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"Previous report showed that USP10 positively regulate TP53."
31695837
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"Western blotting also showed that p53 was reduced dramatically by miR-138 overexpressing, along with the decreased USP10 level (Figure 1E)."
31695837
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"Mechanistically, the interaction between circWSB1 and ubiquitin-specific peptidase 10 (USP10) attenuates the USP10-mediated stabilization of p53 [108]."
40004471
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"Evidence has shown that p53 is degraded through the ubiquitin–proteasome system, and USP10, a deubiquitinase, prevents p53 degradation [52]."
38219869
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"Upon cellular stresses, such as DNA damage or oncogene activation, the TP53 degradation process is attenuated by USP7 and USP10, two deubiquitinating enzymes."
31695837
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"Taken together with the fact that HSPA12A also bound with p53, our data indicate that HSPA12A acted as a scaffolding protein for the binding of both p53 and USP10, by which promoting the USP10-mediated p53 protein stability, and ultimately leading to the inhibition of glycolysis-mediated CF activation."
38219869
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"Also, though we identified the interaction of HSPA12A with p53 and UPS10, the specific binding sites should be characterized in future studies.In conclusion, this study revealed that HSPA12A was a novel inhibitor of CF activation and cardiac fibrosis, and this action of HSPA12A was achieved by inhibiting glycolysis via promoting the USP10-mediated p53 protein stability as a scaffolding protein."
38219869
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"Stable knockdown of USP10 by shRNA inhibited p21 promoter activity in HCT116 p53 +/+ cells, but had little effect in HCT116 p53 -/- cells (XREF_FIG)."
20096447
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"USP10 modulates anterograde and retrograde vesicular trafficking, the localization and stability of p53 and binds Dengue virus RNA."
23141719
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"Wildtype TP53 is usually rescued from proteasomal degradation by USP10."
30107050
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"Conversely, lnc-NR3C knockdown inhibited USP10-triggered p53 activation, thereby protecting cells against oxidative stress."
38388775
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"The alanine mutation of the Thr 42 / Ser 337 has not been shown to interfere with the capability of USP10 to deubiquitinate p53, but it impedes its nucleolar translocation and stabilization, which in effect suppresses USP10 mediated activation of p53 in response to DNA damage [XREF_BIBR]."
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"Upon DNA damage, USP10 deubiquitylates and activates p53."
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