IndraLab

Statements

OTULIN inhibits TNF. 6 / 9
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"OTULIN overexpression significantly suppressed the production of TNF-alpha, IL-1beta, and IL-6 in PM and N9 cells via inhibiting the nuclear translocation of NF-kappaB p65 but had no effect on the pro inflammatory cytokines secreted by un activated microglia, which directly indicates that OTULIN suppressed microglia mediated neuroinflammation by inhibiting the NF-kappaB pathway and attenuated the release of inflammatory mediators under the in vitro ischemic condition."
29544517
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"OTULIN deficiency increases intestinal pathology in TNF emARE mice."
37598207
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"Interestingly, specific loss of OTULIN in myeloid cells has been reported to cause a TNF-dependent ‘cytokine storm’ via enhanced NF-κB activity leading to autoinflammation [67] ."
28325627
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"Consistent with the finding that OTULIN overexpression was shown to delay NF-kappaB activation of TNF, whereas its knockdown was reported to increase the output of NF-kappaB signaling [XREF_BIBR, XREF_BIBR, XREF_BIBR], we found that OTULIN overexpression strongly depressed NF-kappaB activity and reduced the release of TNF-alpha, IL-1beta, and IL-6, which are the primary pro inflammatory cytokines that aggravate brain injury."
29544517
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"Overexpression of OTULIN inhibits TNF signaling (Keusekotten et al., 2013); therefore, we used a retrovirus expression system to express these mutants in OTULIN knock-out (KO) cells to evaluate its function."
38652464
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"Concomitant Loss of OTULIN and CYLD Interaction with HOIP Increases M1Ubiquitination at the TNF-RSC and Enhances TNF Induced Gene Activation."
26670046