IndraLab

Statements

Agonist inhibits IRF3. 3 / 3
| 3
reach
"Results revealed that PLPro suppresses TLR7 agonist-induced production of type I IFNs through inhibiting the IRF-3 activation in the TLR7 signaling pathway."
27164085
reach
"Molecular pathway analyses revealed that RO 90-7501 slightly suppressed poly I:C-induced NFkB activation, but did not apparently alter the TLR3 agonist-induced IRF3 nuclear translocation and IRF3 activated gene (ISG56) expression (data no shown)."
23056170
reach
"Results revealed that PLPro suppresses TLR7 agonist-induced production of type I IFNs through inhibiting the IRF-3 activation in the TLR7 signaling pathway.Besides type I IFN production, we checked whether the TLR7 agonist upregulates pro-inflammatory cytokines."
27164085