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SRC leads to the phosphorylation of AKT on S473. 4 / 4
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"CRF 1 receptors activated by CRF can stimulate a rapid phosphorylation of Akt at Ser 473 that is mediated by upstream Src and PI-3 kinase (Olivares-Reyes & Hauger, unpublished data)."
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"Next, we investigated the roles of c-Src, NADPH oxidase, and PI3K in EGF induced Akt Ser473 phosphorylation."
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"Pretreatment with the PI3K-specific pharmacological inhibitor wortmannin blocked c-Src-induced phosphorylation of AKT S473 and expression of TGIF and MMP2/9 protein ( Fig. 7 B)."
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"Stable transfection of the Src isoform into SYF cells rescued mechanical phosphorylation of Akt Ser 473, while overexpression of Fyn failed to enhance Akt Ser 473 phosphorylation in response to strain (XREF_FIG)."
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