IndraLab

Statements

NFkappaB binds CYLD. 9 / 10
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"To find the association between CYLD and NF-kappaB, we examined the correlation between CYLD and activated NF-kappaB expression."
20414373
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"The Pearson 's correlation test was used to determine the association between activated NF-kappaB and CYLD, with the level of significance set at 0.05."
20414373
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"We show that CYLD deficiency causes constitutive NF-kappaB activation in thymocytes, which is associated with enhanced frequency of Treg cells."
20233721
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"As previously mentioned CYLD can bind to NEMO and NF-kappaB that have been identified as its substrates."
27597804
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"We have shown that NF-κB is constitutively active in our mGluR1-expressing melanoma cells, suggesting the potential involvement of mGluR1 in the CYLD–NF-κB axis [ xref ]."
36139432
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"At this point, CYLD binds to NF-kappaB essential modulator (NEMO)/IKK-gamma and appears to regulate its activity through deubiquitination of TNF receptor associated factor 2 (TRAF 2) [XREF_BIBR]."
20414373
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"NF-κB activation was mechanistically associated with miR-301b-mediated downregulation of CYLD."
30269739
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"NF-κB activation was mechanistically associated with siRNA-mediated downregulation of CYLD."
24495516
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"CYLD mutations are associated with constitutive activation of NF-κB in multiple myeloma cells and B cells from mice deficient for wild-type CYLD exhibited constitutive activation of NF-κB [ xref , xref , xref ]."
23861985