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Statements


Phosphorylated EGFR binds GRB2. 6 / 6
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"Moreover, blocking of the interaction between Grb2 and the phosphorylated EGF receptor with a phosphopeptide corresponding to the EGF receptor Grb2 binding site resulted in inhibition of EGF induced p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Upon EGF stimulation, Grb2 binds phosphorylated EGFR and activates the signaling pathway XREF_BIBR, XREF_BIBR."
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"Furthermore, it has been shown that when quiescent cells are stimulated with epi- dermal growth factor (EGF), Grb2 rapidly binds to the phosphorylated EGF receptor."
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"In response to EGF stimulation, the Grb2 and Sos complex binds to the autophosphorylated EGF receptor [33,51,72,73]."
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"One model to emerge is that Grb2, when bound to phosphorylated EGFR, recruits c-Cbl for the purpose of degrading the receptor and terminating RTK signaling in a classic negative-feedback loop."
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"Although phosphorylated EGFR can bind to both Shc and Grb2, the predominant linkage was observed between EGFR and Shc."