IndraLab
Statements
USP13 activates Neoplasm Invasiveness. 8 / 8
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"It is also noteworthy to point out that USP13 amplifications did not seem to increase B-cell infiltration in LUSC , which has the opposite effect on disease outcome [ 38 ] ."
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"Finally, Snail knockdown significantly blocked USP13-induced SGC-7901 cell migration and invasion."
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"Next, USP13 knockdown prominently reduced the proliferation, epithelial-mesenchymal transition (EMT), migration, and invasion of Hep3B and Huh7 cells, while USP13 overexpression enhanced these biological behaviors of HepG2 and LO2 cells."
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"On the other hand, although USP13 arm-level gains and high amplifications significantly increased lymphocyte infiltration in HNSC, OV and STAD, higher USP13 levels were correlated with shorter survival in ovarian and gastric cancers."
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"It is also noteworthy to point out that USP13 amplifications did not seem to increase B-cell infiltration in LUSC, which has the opposite effect on disease outcome [38]."
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"We found that the effect of USP13 in promoting the migration and invasion capacities of breast cancer cells can at least partly be achieved through its regulation of Twist1, while Twist1 can inhibit the transcriptional activity of USP13."