IndraLab

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SGCG increases the amount of USP18. 2 / 2
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"The expression of USP18 is strongly induced by type I and type III interferons [2] [3] [4] [5] , by the Toll-like receptor (TLR) agonists LPS [6] [7] [8] and polyI:C [6] (synthetic analogy of dsRNA) and by TNFα [7] ."
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"ISG15 silencing decreased the amount of USP18 protein in recombinant IFN-λ4-treated cells, and the protein level of USP18 was restored not only by transfection of wild type (WT) ISG15 gene but also by transfection of conjugation-defective ISG15 AA mutant gene (Supplementary Fig. 8A)."
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