IndraLab

Statements

STK11 inhibits MTOR. 139 / 144
| 5 127 7
reach
"During starvation, Lkb1, an upstream kinase of AMPK, represses mTOR, which induces a reversible glycolytic and epigenetically H4K16Ac negative, diapause like state."
31991105
reach
"To investigate the mechanisms underlying LKB1-deletion-caused follicular over-activation, we first focused on the mTOR pathway, which balances cell growth with energy control and is also negatively regulated by LKB1 through AMPK."
26745759
sparser
"Lkb1, the upstream kinase of AMPK, inhibits mTOR, thereby inducing reversible embryonic diapause [ xref ]."
38399515
reach
"As expected, the loss of both Lkb1 and Pten in these tumors activated the AKT and mTOR pathways, likely driving cellular proliferation and tumorigenesis."
24794706
reach
"In response to energy stress, Lkb1, a kinase known to activate several AMP activated protein kinases (AMPK), inhibits the canonical mTOR pathway and impedes protein translation and cell growth."
24067363
reach
"Ectopic expression of LKB1 with stable transduction system or inducible expression construct in endogenous LKB1 deficient cells improved the activation of AMPK, promoted the inhibition of mTOR, and prompted the sensitivity of cells to metformin."
22735790
eidos
"STK11 inhibits mTOR signaling through activation of AMPK , and in cancer cells with loss of AMPK activity , mTOR becomes an oncogenic driver46 ."
34870237
reach
"Lkb1 and Pten Synergise to Suppress mTOR Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in the Mouse Bladder."
21283818
sparser
"The most likely antiproliferative mechanism of metformin was reportedly associated with its ability to activate AMPK and LKB1, which inhibits the mechanistic target of rapamycin (mTOR) (a commonly dysregulated pathway in cancer) and consequently inhibit protein synthesis and cell proliferation [ xref ]."
39796103
sparser
"AMPK is also a central mediator of liver kinase B1, which inhibits mTOR."
33809200
reach
"Previous studies reported that LKB1 may repress mTOR in an AMPK- and tuberous sclerosis complex 2 (TSC2)-dependent manner in tumors [11,12] ."
27235551
reach
"Previous studies reported that LKB1 may repress mTOR in an AMPK-dependent manner in tumors [11,12] ."
27235551
reach
"Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1."
22916036
reach
"To this end, it has been shown that LKB1 inhibits mTOR signaling in an AMPK- and TSC2-dependent manner [56] ."
23287077
reach
"Studies have shown that LKB1 deficiency can activate mTOR to upregulate the serine synthesis pathway (SSP) and promote tumor progression."
39327097
sparser
"Additionally, HeLa cells are defective in the tumor suppressor LKB1, which inhibits mTOR via TSC2 stimulation."
25045438
sparser
"Metformin acts as an anti-tumor medication through stimulation of AMP-activated protein kinase (AMPK) and its regulator liver kinase B1 (LKB1), which inhibits the mammalian target of rapamycin (mTOR) and disrupts the life cycle of cancer cells."
28978007
reach
"STK11 negatively regulates the mTOR pathway by activation of AMPK [XREF_BIBR]."
33652656
eidos
"Generally , metformin inhibits mammalian Target of Rapamycin ( mTOR ) activity by activating ATM ( ataxia telangiectasia mutated ) , Liver Kinase B1 ( LKB1 ) , and then AMPK , which ultimately prevents protein synthesis and cell growth [ 6 ] ."
33604594
reach
"Moreover, the activation of LKB1 and AMPK stimulates autophagy through phosphorylation of ULK1 and inhibits the mTOR pathway."
33867999
reach
"LKB1 acts through AMPK to inhibit mTOR, which regulates cell growth."
25714017
reach
"In our model the combined deletion of both Lkb1 and Pten in the mouse bladder drastically activates mTOR pathway and this precise activation serves as a signal for EMT program execution (XREF_FIG)."
21283818
reach
"Conclusion SIRT4 could exert its tumor suppressive function in HCC by inhibiting glutamine metabolism and thereby increasing the ADP and AMP levels to phosphorylate AMPKalpha via LKB1, which blocks mTOR signaling pathway."
30552782
reach
"Interestingly, mTOR related gene sets had similar expression levels in STK11 ex1-2 and STK11 ex3-9, confirming that both types of tumor share the loss of STK11 tumor suppressor activity and subsequent activation of the mTOR pathway."
26625312
reach
"In this study, we investigate whether IL11-stimulated ERK/P90RSK can phosphorylate LKB1 (STK11) to inactivate LKB1/AMPK and increase mTOR activity."
35992082
reach
"In our pathway inhibitor analysis ( Fig. 8 ), we found the loss of LKB1 increased mTOR activation, and treating these cells with mTOR inhibitor significantly decreased FN and Col-I expression."
36812767
reach
"It has been demonstrated that LKB1 negatively regulates mTOR signaling through phosphorylation of AMPK at Thr172 site [33] ."
31513784
reach
"The LKB1 and AMPK signaling negatively regulates mTOR signaling."
25914534
reach
"25 LKB1 deficiency has been shown to activate mTOR to upregulate tumor serine synthesis and promote tumor progression."
39327097
reach
"Meanwhile, the mTOR/p70S6K system was activated by their phosphorylation status (p-mTOR on Ser 2448 and p-p70S6K on Thr421/Ser424, respectively) [9,25] , but inhibited by the LKB1/AMPK signaling pathw[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25817233
reach
"One feasible reason is that the dosage of GA employed in the in vivo experiment or the concentration of drug in tissues is not enough to achieve the inhibition on mTOR signalings which can be up-regul[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31513784
reach
"In non small cell lung cancer cells, LKB1 and AMPK signaling negatively regulates mTOR activity and contributes to cell growth inhibition in response to energy stress."
23178462
reach
"In order to more rigorously examine the requirement of AMPK for LKB1 mediated inhibition of mTOR signaling, we introduced wild-type LKB1 into HeLa cells with or without two different dominant negative[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15261145
reach
"Medical therapy is therefore a very attractive proposition.Given the mTOR pathway is dysregulated by variants in LKB1 , rapamycin is an obvious candidate for a chemoprevention agent in PJS."
35988959
reach
"However, most frequently, RSV is found to inhibit the activity of the mTOR pathway proteins, and to activate AMPK and LKB1, which can suppress mTOR signalling."
24060150
reach
"It is known that LKB1 negatively regulates mTOR through AMPK, while SRC positively regulates it through PI3K and AKT signaling [XREF_BIBR; XREF_BIBR]."
21450399
sparser
"Moreover, the disulfide ATM dimer triggers a signaling pathway through LKB1 that inactivates mTOR, the main negative regulator of autophagy, thereby promoting the activation of the cell-defense autoph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22846600
reach
"In NSCLC cells in vitro, LKB1 and AMPK signaling was shown to negatively regulate mTOR activity and contribute to cell growth inhibition in response to 2-deoxyglucose (2-DG), which mimics energy stress."
23875169
reach
"This is often related to elevated mTOR activity caused by loss-of-function mutations in the tumor suppressors LKB1, PTEN, or TSC."
36428613
reach
"PTEN inhibits PI3K signaling in the absence of growth factors, and STK11 (LKB1) inhibits MTOR activity when ATP is low [XREF_BIBR]."
22979947
reach
"In non-small cell lung cancer, the LKB1/AMPK axis suppresses mTOR activity and promotes cell growth inhibition [51]."
| PMC
reach
"A key role of LKB1 is to negatively regulate the activity of mTOR complex 1 (mTORC1)."
23668926
reach
"Notably, we observed over-expression of AKT3 (an mTOR activator) and reduced expression of TSC2 (consistent with single copy loss of the gene) and STK11 which both inhibit mTOR activity."
27799065
reach
"Additionally, LKB1 inhibits the mTOR pathway [205]."
39057027
reach
"While PTEN loss increases PIK3CA activity, LKB1 loss-of-function promotes mTOR signaling."
26842989
reach
"In addition to PTEN, the LKB1 tumor suppressor pathway also negatively regulates mTOR signaling."
24322983
reach
"Because LKB1 and AMPK signaling inhibits mTOR, but activated Akt stimulates mTOR activity, LKB1 and Akt are thought to play opposing roles with regard to mTOR regulation."
18794113
reach
"In particular, the loss of LKB1 inhibits the negative regulation of mTOR and, consequently, leads to the activation of the pathway."
35456982
reach
"This was a groundbreaking study because it provided in vivo evidence that the inactivation of LKB1 not only disrupts the regulation of mTOR signaling but also promotes cancer metastasis."
25679014
reach
"As LKB1 indirectly suppresses mTOR signalling via AMPK, LKB1 deletion increases mTOR signalling, as does mutant PIK3CA via AKT signalling."
30991934
reach
"While these additional effects are intriguing, LKB1 dependent suppression of mTOR signaling remains the key candidate mechanism of antitumor action of metformin."
21470407
reach
"MTOR pathway deregulation is an obvious candidate since Lkb1 negatively regulates mTOR via AMPK/TSC2 [75,76] ."
21241696
reach
"In summary, LKB1 negatively regulates mTOR signaling through its substrate AMPK, and the loss of LKB1 leads to the aberrant activation of mTOR in a variety of tissues."
23668926
reach
"Since LKB1 is known to downregulate mTOR signaling by activating the AMPK signaling pathway 7, we further investigated the effect of p53 on LKB1 regulated AMPK and mTOR pathway."
25042259
reach
"This effect is mediated by LKB1 signaling via AMPK, which causes the inhibition of mTOR [105,106]."
38892400
reach
"In contrast, we found that only LKB1 deficient cells effectively suppressed mTOR signaling and induced PARP cleavage in response to erlotinib treatments, both in vitro and in vivo."
26119936
reach
"It was proposed that this inhibition of LKB1, which dampened AMPK signaling, thus potentiated mTOR activity and ultimately enhanced cell growth and proliferation."
21450399
reach
"Pten and Lkb1 have been revealed as potent tumor suppressors of endometrial cancer in experimental mouse models, both of which also converge on and negatively regulate mTOR signaling."
24322983
reach
"Liver kinase B1 (LKB1), a regulator of AMP activated protein kinase (AMPK), mammalian target of rapamycin complex 1 (mTORC1) and FOXO pathways, links sensing and metabolism and is required for maintaining energy homeostasis."
23698583
reach
"Through inhibition of glucose uptake, EGFR TKI triggered AMPK activation in an LKB1 dependent manner due to the reduction of ATP level to suppress mTOR signaling and tumor growth."
33335306
reach
"LKB1 tumour-suppressor activity is caused partly by AMPK-mediated inhibition of inappropriate mTOR activation."
31919406
reach
"Fluid shear-induced cilia activation through tumor suppressor protein liver kinase B1 can repress mTOR signaling, which in turn regulate cell size and proliferation [99]."
37722182
reach
"Additionally, LKB1 inhibited Yap independently of either AMPK or mTOR activation."
23027127
reach
"In the presence of elevated adenosine monophosphate (AMP)/adenosine triphosphate (ATP) and adenosine diphosphate (ADP)/ATP ratios, AMPK is activated by the upstream signal LKB1; Then, the activated LK[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35680037
reach
"More recent work has shown that a splice variant of Lkb1, a key metabolic regulator, can inhibit mTOR via increased Ampk signalling [38] ."
38604005
eidos
"By directly controlling the activation of these kinases , LKB1 inhibits mammalian target of rapamycin ( mTOR ) , a tumor-promoting kinase , and activates tuberous sclerosis 2 ( TSC2 ) and p53 , both of which are tumor suppressors 16 , 18 , 19 , 20 , 21 ."
30548122
reach
"LKB1 mediates energy-dependent suppression of the mTOR pathway via AMPK."
23280187
eidos
"STK11 ( LKB1 ) inhibited mTOR signaling ."
32419983
reach
"Hence, a substantial decrease in circZNF559 expression in CPT-derived P-SSCs may contribute to the development of the tibia, offering a possible approach for treating CPT.Osteosarcoma is caused by the deletion of liver kinase b1 (Lkb1) via Ctsk-Cre, which activates mammalian target of rapamycin complex 1 (mTORC1) [75] (Fig. 3D and Table 3)."
40160808
reach
"In support of this, LKB1 has been shown to inhibit the mTOR (mammalian target of rapamycin) pathway and to interact with p53 to mediate p53-dependent apoptosis [40,48,52–55] ."
18314332
reach
"LKB1 and AMPK dependent inhibition of the mTOR pathway acts as a tumor suppressor in transformed cells, contributing to cell growth inhibition and repression of oncogenic mRNA translation in response to energy stress [XREF_BIBR, XREF_BIBR]."
26798768
reach
"The loss of Lkb1 in periosteal mesenchymal progenitor cells induces osteoblastogenesis by activating the mammalian target of rapamycin complex 1 (mTORC1) [19]."
36499390
reach
"PTEN and LKB1 loss synergistically enhances the activation of AKT and mTOR pathway, promotes the proliferation of pNET cell lines and confers the attenuated sensitivity of pNET cells to mTOR inhibitors."
29228674
reach
"LKB1 was found to negatively regulate the activities of mTOR, FAK and Src, and YAP1, and LKB1-mutant cells may become dependent on the hyper-activation of these signaling pathways."
25679014
reach
"Although numerous pathways have been implicated in the antineoplastic effects of metformin, LKB1-dependent suppression of mTOR signaling remains the main candidate mechanism."
23277337
reach
"Thus, Lkb1, a multifunctional nutrient sensing kinase, is required to maintain HSC quiescence under reduced nutrient conditions and loss of Lkb1 promotes lineage commitment and HSC exhaustion in an mTOR independent manner XREF_BIBR - XREF_BIBR."
23142822
reach
"Mammalian target of rapamycin complex 1 (mTORC1) is inhibited by the LKB1/AMPK pathway, via tuberculous sclerosis complex 1 and 2 (TSC1 and TSC2) activation, which induces protein synthesis disruption and inhibition of tumor cell proliferation."
36397350
reach
"SIRT3 can increase the deacetylation level and activity of LKB1 (Woods et al. 2003), which in turn promotes the phosphorylation level and activity of AMP activated protein kinase (AMPK) (Pillai et al. 2010) and inhibits the activity of mTOR, thereby promoting autophagy (Jung et al. 2010)."
36374406
reach
"Interestingly, the smallest impact on metabolism was seen in NCI-H1568 and NCI-H1944 that are both STK11-inactivated, which results in decreased AMPK activation and increased mTOR signaling, potentially protecting the cells from this effect of tipifarnib.The observed altered metabolism can also be linked to ferroptosis, a form of regulated cell death caused by peroxidation of lipids due to high levels of ROS and intracellular iron."
39995872
reach
"An additional link between Reelin and mTor signaling is suggested by the reciprocal regulation of Golgi morphology by Reelin-Dab1 and Lkb1 signaling, which also inhibits mTor by activating Tsc2."
27445693
reach
"It has been reported in a variety of tissues that the inhibition of LKB1 signaling induced the aberrant activation of the mTOR signaling pathway."
29022902
reach
"The serine/threonine kinase mTOR is a master regulator of cell growth and metabolism and is negatively regulated by LKB1 (also known as serine/threonine kinase 11 or STK11) [13]."
37573301
reach
"Pathogenic mutations of STK11/LKB1 lead to inactivation of its expression product and loss of inhibition of mammalian target of rapamycin (mTOR) activity, which leads to abnormal activation of the LKB1/mTOR signal pathway and the occurrence of black spots on the skin and gastrointestinal hamartoma polyps[5]."
34754157
reach
"Mechanistically, APE up-regulated the expression of SIRT1, activated LKB1 and AMPK pathway and inhibited mTOR signaling."
33037751
reach
"Loss of LKB1 activates the mTOR pathway and promotes cell growth, survival and tumorigenesis in acute myeloid leukemia, squamous cell carcinoma of skin, and squamous cell carcinoma of lung via LKB1 and AMPK regulation [XREF_BIBR - XREF_BIBR]."
29228674
reach
"The LKB1, a tumor suppressor kinase located in PC on epithelial cells, is known to inhibit mTOR activation by inhibiting AMPK signaling, which represses tumor cell polarization and metastasis (47, 50)."
38260150
reach
"STK11 (LKB1) inhibited mTOR signaling."
32419983
reach
"In mouse endometrial and bladder cancers, loss of PTEN and LKB1 leads to activation of the AKT and mTOR pathway and results in tumors sensitivity to PI3K and mTOR inhibition."
29228674
reach
"Additionally, HeLa cells are defective in the tumor suppressor LKB1, which inhibits mTOR via TSC2 stimulation."
25045438
reach
"STK11 inhibits mTOR signaling through activation of AMPK, and in cancer cells with loss of AMPK activity, mTOR becomes an oncogenic driver ."
34870237
reach
"Of interest, HeLa cells are defective in the tumor suppressor protein LKB1, also known as STK11, which inhibits mTOR by a pathway impinging on TSC2 stimulation."
22409888
reach
"It has been known that the cross-talk between the Ras/Raf and the LKB1/AMPK/mTOR signaling pathways seems to regulate the cellular response to autophagy-inducing signals [39] LKB1 encodes a serine-thr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21775053
eidos
"Liver kinase B1 ( LKB1 , tumour suppressor ) , an upstream kinase of AMP-activated protein kinase ( AMPK ) induces AMPK phosphorylation of tuberous sclerosis complex 2 ( TSC2 ) to suppress Ras homolog enriched in brain ( Rheb ) and inhibit mTOR ."
33440869
reach
"The tumor suppressors liver kinase B1 (LKB1) and AMPK regulate cell growth in response to changes in environmental nutrient levels and generally downregulate the mTOR pathway, resulting in reduced protein synthesis and the development of sarcopenia [93]."
38267975
reach
"In a mouse model of bladder cancer, Shorning et al. demonstrated that loss of LKB1 (upstream kinase of AMPKalpha) and PTEN synergizes to activate AMPK and mTOR and that rapamycin treatment reduced tumor burden in mice XREF_BIBR."
27916296
reach
"This suggested that LKB1 inhibits Yap independently of mTOR."
23027127
reach
"The mTOR signaling is negatively regulated by LKB1 (liver kinase B1) and its downstream target AMP activated protein kinase (AMPK), two master nutrient sensors, that sense cellular stress (e.g., limiting ATP levels) and promote FAO in CD8 T cell memory and Treg cells (XREF_FIG) [XREF_BIBR], [XREF_BIBR]."
25563988
reach
"STK11 encodes a serine/threonine kinase called LKB1 that activates AMPK and negatively regulates the mTOR pathway in response to changes in cellular energy levels."
28550065
reach
"To assess whether the loss of LKB1 leads to mTOR dependent glucose addiction in breast cancer, we analyzed the glycolytic profile of NIC tumor cells in response to glucose availability."
24280377
reach
"In particular, GNA11 can act as an oncoprotein by activating mTOR signaling, whereas STK11 inhibits mTOR activity downstream of PTEN."
28188128
reach
"STK11 also negatively regulates mammalian target of rapamycin (mTOR) signaling through its substrate AMPK, and the loss of STK11 leads to the aberrant activation of mTOR in a variety of tissues, with a case study showing usefulness of the mTor inhibitor everolimus for therapy (5-6) (Figure 1)."
33744718
reach
"In contrast, tumor suppressor proteins such as PTEN, AMPK, STK11 and LKB1 and TSC1/2, can negatively regulate MTOR and enhance autophagy.60 Studies have identified aberrant ATG genes and ATG protein expression profiles in OSCC tissues or cell lines, including LC3, BECN1, ATG16L1, LC3, BECN1, ATG9A, SQSTM1 and ATG5.15,16,21,22,25-28 Recent data on the autophagic activity in OSCCs are summarized in Table 1."
27764582
reach
"Lkb1, the upstream kinase of AMPK, inhibits mTOR, thereby inducing reversible embryonic diapause [55]."
38399515
reach
"The intestinal polyps in Peutz-Jeghers syndrome have up-regulated mTORC1 signaling, supporting the idea that STK11 loss results in mTOR activation (7)."
33744718
reach
"MTOR is activated by HR HPV oncogene, XREF_BIBR - XREF_BIBR but inactivated by LKB1."
27546620
reach
"It is said that Lkb1 and PTEN are able to synergistically inhibit mTOR to disrupt nuclear translocation of Snail and EMT induction, leading to suppression of tumorigenesis ( Shorning et al., 2011 )."
32485246
reach
"While the inhibition of mTOR activity as well as activation by the tumor suppressor LKB1 serve as a basis for AMPK 's anti-tumor effects, induction of potentially pro survival pathways like autophagy and glucose uptake have been proposed to challenge the molecule 's anti-cancer role [XREF_BIBR]."
29534438
reach
"Considering the finding that LKB1 negatively regulates mTOR through AMPK and TSC2 [XREF_BIBR], all these observations suggest that mTOR inhibitors may suppress PJS associated cancers in addition to Peutz-Jeghers polyposis."
19147279
reach
"For example, activation of the LKB1 and AMPK pathway inhibits mTOR in an Akt independent manner."
20028747
reach
"MTOR signaling, which is also inhibited by LKB1, remains upregulated in BCCs."
21272562
reach
"In addition, here we showed that loss of LKB1 could induce constitutive mTOR activation, even in the absence of detection of p-TSC2 (Thr 1462), and in vitro gain of LKB1 in OS cell lines shows a tumourigenic function."
28632727
reach
"Importantly, SIRTs can activate LKB1, which in turn can activate AMPK and downregulate mTOR (Woods et al., 2003; Shaw, 2009; Sadria & Layton, 2021) and regulate PGC-1α (Cantó et al., 2013)."
37334045
reach
"When ATP levels are restored or normalized to sustain cellular needs, mTOR inhibition is suppressed by the decreased activity of the LKB1 complex, as previously reported [73,74,75,86]."
38927242
reach
"Loss of function pathogenic variants in STK11 cause a decrease in the inhibition of mTOR, resulting in uncontrolled cell growth [93]."
31469018
reach
"Furthermore, hLKB1 DeltaLB C430A is no longer able to inhibit mTOR (as estimated by phosphorylation of p70-S6-Kinase 1, pS6K, XREF_FIG)."
28649994
reach
"69 Loss of LKB1 leads to activation of the mTOR and IGF-1R pathways."
25992224
reach
"Although mTOR is a known regulator of the cell size XREF_BIBR and Lkb1 can suppress mTOR via AMPK phosphorylation XREF_BIBR we did not find evidence of mTOR machinery misregulation in our model (XREF_FIG) suggesting relatively intact energy sensing mechanisms."
19165340
reach
"Melanocytic nevi, a benign proliferation of melanocytes, which can give birth to malignant melanoma, show in many cases elevated PLD2 expression as well as activation of Akt, whereas LKB1 expression is still high in most cases, suppressing aberrant mTOR activation, which occurred only in 25% of the analysed specimen (XREF_FIG)."
28649994
reach
"It is thought that MET in culture conditions with high concentrations of glucose stimulates AMPK through an LKB1-dependent mechanism, which blocks mTOR, causing a powerful inhibition of cell proliferation in several types of cancer cells specially non-TN breast cancer cells (21, 25, 26)."
30483391
reach
"This is also consistent with our observation that LKB1 and AMPK upregulation failed to block mTOR signaling."
21272562
reach
"It had previously been suggested that loss of Lkb1 activity in Pkd1 mutant kidney epithelia promoted activation of the mTOR pathway and a switch in cellular metabolism towards glycolysis, a phenomenon referred to as the Warburg effect 23."
29483507
reach
"It is likely that inability of LKB1 to effectively downregulate mTOR may be related to its failure to block tumorigenesis."
21272562
reach
"Second, in HeLa and pMEP4-LKB 1 inducible cells, induction of LKB1 decreased the activation of mTOR (phospho-mTOR, XREF_FIG, XREF_SUPPLEMENTARY) while enhancing the activation of AMP activated protein kinase (AMPK) as reflected by an increase in the phosphorylation of acetyl-CoA carboxylase (ACC), a substrate of the LKB1-AMPK cascade (XREF_FIG)."
27546620
reach
"Another study demonstrated that galangin induced autophagy and apoptosis in HepG2 cells by mediating the phosphorylation of AMPK and liver kinase B1 (LKB1), thereby suppressing the activity of mTOR an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36049673
reach
"Moreover, the tumor suppressor LKB1 negatively regulates the mTOR axis."
19694499
reach
"Since the PI3K and Akt and MAPK and ERK signaling pathways, which positively regulate the mTOR axis, are often activated in many types of cancer, and LKB1, which suppresses mTOR signaling, is frequently mutated in certain types of cancers, mTOR signaling is consequently hyper-activated in many types of cancers."
19694499
reach
"The tumor suppressor liver kinase B1 (LKB1) and AMPK control cell growth in response to environmental nutrient changes and downregulate the mTOR pathway [XREF_BIBR, XREF_BIBR]."
29463451
reach
"AMPK is an essential downstream effector of the tumor suppressor LKB1, which signals to COX-2 (cancer progression), ULK1/2 (autophagy), ACC1/2 (Fatty acid metabolism), mTOR (cell growth and protein synthesis), and p53 (apoptosis) (113–115)."
36479072
reach
"The LKB1 and AMPK pathway on the other hand, inhibits mTOR and activates NF-kappaB and Notch1."
21555366
reach
"Specifically, LKB1-activated AMPK negatively regulates mTOR activity."
32819560
reach
"Moreover, GA increases LKB1 expression and suppresses mTOR signaling by activating AMPK in lung cancer [32]."
35744960
reach
"Deletion of Lkb1 in adipose tissues has been reported to activate the mTOR pathway in BAT through inhibition of AMPK activity."
29032027
reach
"While likely not completely delineated, it is thought that metformin activates AMPK via an LKB1-dependent mechanism, which inhibits the mammalian target of rapamycin (mTOR) resulting in a strong inhib[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24462945
reach
"Our studies reveal two additional players, LKB1 and AMPK, that negatively regulate mTOR, in the tubulation cascade."
34607961
reach
"In contrast, states of energy or nutrient deprivation may trigger other upstream pathways, such as the LKB1 and AMPK pathway, which ultimately inhibits mTOR activity and limits cell growth and metabolism."
23644232
reach
"Metformin regulates the adenosine monophosphate-activated protein kinase (AMPK) and liver kinase B1 (LKB1) pathways, which inhibit the mammalian target of rapamycin (mTOR)."
36361684
reach
"LKB1 and AMPK axis activation is known to downregulate mTOR signaling under conditions of nutrient deprivation [XREF_BIBR, XREF_BIBR]."
21272562
sparser
"STK11 inhibits mTOR directly via alteration of the TSC1–TSC2 complex upstream of mTOR."
22732638
reach
"STK11 encodes serine/threonine protein kinase 11, also known as Lkb1, that activates AMPK, and negatively regulates the mTOR pathway in response to cellular energy levels."
26425723