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USP14 increases the amount of HIF1-α. 2 / 2

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"Furthermore, overexpression of USP14 significantly upregulated the transcription of the endogenous HIF1-α target genes, including MET, VEGF-A, and MMP2 (Fig. 2C)."

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"USP14 depletion significantly decreased HIF1-α protein level, but not HIF1-α mRNA level in HCC cells, suggesting that USP14 may be involved in the maintenance of HIF1-α stability (Fig. 2E, F, Figure S2D)."

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USP14 increases the amount of HIF1-α. 2 / 2

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