IndraLab

Statements

IL1B binds IL1R1 and IL-1α. 54 / 54
| 54
sparser
"When either IL-1β or IL-1α binds to IL-1R1, a structural change takes place allowing IL-1R3 to bind and to form a heterotrimeric complex ( xref )."
32324502
sparser
"The IL-1 pathway is triggered when the ligands IL-1α and IL-1β bind to IL-1R1, which forms a complex with the IL-1 receptor accessory protein (IL-1RAcP) xref ."
32206125
sparser
"By mirroring the mode of action of the endogenous form, anakinra inhibits the binding of IL-1α and IL-1β to IL-1R, and it has been approved for the treatment of rheumatoid arthritis, adult-onset Still’s disease, and certain periodic fever syndromes (such as familial Mediterranean fever)."
33110739
sparser
"In contrast, IL-1Ra acts as an antagonist of IL-1R1, preventing the binding of IL-1α and IL-1β with IL-1R1, respectively."
27294501
sparser
"Binding of IL-1R1 with IL-1α or IL-1β leads to subsequent recruitment of IL-1RAcP at the cell membrane [ xref ] and downstream cytosolic NF-κB activation."
25706624
sparser
"IL-1ra is a cytokine produced by monocytes, macrophages, and dendritic cells, which prevents the binding of IL-1α as well as IL-1β to IL-1R1 by competitively blocking IL-1RI receptors [ xref , xref ]."
32384874
sparser
"Although both IL-1α and IL-1β can interact with IL-1R1 to induce downstream transcription of inflammatory genes, they show considerable differences in their localization, regulation, and function."
28706254
sparser
"a IL-1R1 interacts with both IL-1α and IL-1β and promotes signal transduction, together with its co-receptor IL-1R3 (IL-1RAcP)."
31182982
sparser
"It can block the binding of both IL-1α and IL-1β to IL-1R [ xref ]."
33608746
sparser
"It inhibits the signaling pathways through activated IL-1R by interrupting interaction of IL-1α and IL-1β with IL-1R [ xref ]."
33572274
sparser
"Anakinra is an IL-1R antagonist that inhibits the binding of IL-1α and IL-1β to IL-1R and prevents inflammation [ xref ]."
25852877
sparser
"IL-1α and IL-1β bind to the IL-1R, which induces the release of chemokines and recruitment of neutrophils xref , xref ."
25760420
sparser
"ST2 is a member of the IL-1 receptor family; it was originally identified as being induced by serum or oncogene expression in mouse fibroblasts ( xref , xref ), and it does not bind IL-1α, IL-1β, or IL-1R antagonist ( xref – xref )."
28114842
sparser
"The IL-1 family consists of two related polypeptides, IL-1α and IL-1β that bind to the same primary receptor IL-1R1, which is expressed by almost all cell types, and can recruit and/or activate a variety of immune cells and immunocompetent cells, such as macrophages, endothelial cells, neutrophils, and epithelial cells."
34475751
sparser
"Indeed, it is true that recombinant IL-1α and IL-1β both bind to IL-1R to induce a proinflammatory signaling cascade."
23087690
sparser
"Blocking IL-1 entered the clinical arena with anakinra, the recombinant form of the naturally occurring IL-1 receptor antagonist (IL-1Ra); IL-1Ra prevents the binding of IL-1α as well as IL-1β to IL-1R1."
30459597
sparser
"Anakinra as IL-1RA binds to the IL-1R and consequently prevents the binding of IL-1α as well as IL-1β to IL-1R1 and blocks their activity [ xref , xref ]."
34063964
sparser
"Although they are structurally very different, both IL-1α and IL-1β bind to the IL-1Rs and the neurochemical effects of both forms are similar ( xref )."
30013513
sparser
"Anakinra is a recombinant IL-1R antagonist that blocks the binding of both IL-1α and IL-1β to IL-1R, thereby inhibiting the proinflammatory effects of IL-1."
34636334
sparser
"Two isoforms of IL-1 exist, IL-1α and IL-1β, which bind the same receptor IL-1R but are encoded by two different genes."
34604096
sparser
"It inhibits the signaling pathways through activated IL-1R by interrupting interaction of IL-1α and IL-1β with IL-1R [126]."
33572274
sparser
"IL-1Ra, encoded by IL-1RN , can also compete with the binding of IL-1α and IL-1β to the IL-1R complex."
32067109
sparser
"Both IL-1α and IL-1β bind to IL-1R1 and form an activating complex with the signaling chain IL-1R3."
28642703
sparser
"The IL-1 receptor type 3 (IL-1R3) acts as a co-receptor for IL-1R1, being responsible for signaling after the binding of IL-1α or IL-1β to IL-1R1 (Kaneko et al., 2019)."
34707513
sparser
"And the higher affinity of TFMG to the base location indicated that it can significantly inhibit the IFN γ interaction with its receptor Interleukin -1(IL1) is the molecular mediator of inflammatory diseases and it mediates its function through the interaction with IL-1α, IL-1β and IL-1R."
35403090
sparser
"Importantly, IL-1α and IL-1β both bind the IL-1R, but the role for IL-1α is poorly understood in most disease conditions."
31186281
sparser
"When IL-1α or IL-1β bind to IL-1R1, a structural change occurs so that IL-1R3 interacts with IL-1R1 forming a heterotrimeric complex thereby initiating intracellular signalling."
36209522
sparser
"After binding of IL-1α or IL-1β to the IL-1R1, a complex signaling cascade is activated, eventually leading to “nuclear factor kappa-light-chain-enhancer of activated B cells” (NFκB) production and subsequent gene transcription [ xref ]."
28109186
sparser
"Anakinra was the first recombinant 3 IL-1R antagonist (rHIL-1Ra) that blocks the binding of both IL-1α and IL-1β to IL-1R, thus 4 minimize the proinflammatory effects of IL-1 [107]."
33278517
sparser
"Initiating intracellular signaling via the IL-1R1 system is a multistep process involving: IL-1α or IL-1β binding to the extracellular domain of IL-1R1, recruitment of accessory proteins (e.g., the co-receptor IL-1R1 accessory protein (IL-1RAcP)), formation of a receptor heterodimeric complex (comprised of IL-1α or IL-1β, IL-1RI, and IL-1RAcP), and assemblage of intracellular adaptor proteins."
25479427
sparser
"IL-1R1, which binds to both IL-1α and IL-1β, can be detected in a variety of cell types, whereas the IL-1R2 is found on the cell surface of type B lymphocytes, neutrophils and macrophage, and binds with IL-1β with higher affinity[ xref ]."
24006091
sparser
"IL-1α and IL-1β bind specifically to IL-1R1, IL-18 to IL-18Rα, IL-33 to ST2 and IL-36α, IL-36β, and IL-36γ to IL-36R ( xref )."
33796114
sparser
"It blocks the binding of IL-1β and IL-1α to their receptor IL-1R and hence blocks IL-1 activity [ xref ]."
32663575
sparser
"Anakinra was the first recombinant IL-1R antagonist (rHIL-1Ra) that blocks the binding of both IL-1α and IL-1β to IL-1R, thus minimize the proinflammatory effects of IL-1 [ xref ]."
33278517
sparser
"Anakinra blocks the binding of both IL-1α and IL-1β to IL-1R, thereby inhibits the proinflammatory effects of IL-1 [ xref ]."
| PMC
sparser
"Both IL-1α and IL-1β bind to same IL-1R, and bone marrow-derived macrophages produced both IL-1α and IL-1β in response to LCWE in vitro ( xref )."
26941015
sparser
"Both IL-1α and IL-1β bind to IL-1R1, thereby enabling recruitment of its co-receptor IL-1RAc."
32550001
sparser
"Following binding of IL-1α or IL-1β to the type I IL-1R, a second protein, the IL-1 receptor accessory protein (AcP), is recruited to the complex (Greenfeder et al., 1995) ."
12530978
sparser
"Because mice deficient in the IL-1R cannot respond to IL-1, this result demonstrated that either IL-1α or IL-1β, both of which bind to the IL-1R, contributed to acute pathology after rVSV immunization."
23056330
sparser
"IL-1α and IL-1β bind to IL-1R1 complexed to the IL-1 receptor accessory protein and induce similar physiological effects."
25764208
sparser
"Transmigration occurs as an interaction of cellular adhesion molecules and integrins. (B) The recruitment of mature DCs is facilitated by expression of CCR7 and IL-1R that increases attraction by secreted CCL19, CCL21 or IL-1α and IL-1β, respectively. (C) Immature DCs can also be attracted by interaction of IL-1α or IL-1β with IL-1R, but their expression of CCR2, CCR3, and CCR5 increases the interactions with CCL2, CCL3, and CCL5."
35529884
sparser
"IL-1RA blocks the binding of IL-1α and IL-1β to IL-1R1, having no cross-reactivity with IL-1α and IL-1β [ xref ]."
35048046
sparser
"As IL-1α and IL-1β both bind to the IL-1R and are antagonized by Anakinra, ASC-independent release of IL-1α may make an important contribution to DDA/TDB-induced Th induction."
23308247
sparser
"Of these, IL-1R1 binds IL-1α and IL-1β recruiting IL-1R3 to form the trimeric signaling complex."
31427775
sparser
"IL-1α and IL-1β bind to IL-1R1, leading to the activation of IL-1 signal-regulated innate immune and inflammatory physiological functions."
28585438
sparser
"Anakinra as IL-1RA binds to the IL-1R and consequently prevents the binding of IL-1α as well as IL-1β to IL-1R1 and blocks their activity [110, 111] ."
34063964
sparser
"IL-1α and IL-1β both bind the IL-1R, which is critical for control of L. pneumophila infection."
31351897
sparser
"Anakinra was the first recombinant IL-1R antagonist (rHIL-1Ra) that blocks the binding of both IL-1α and IL-1β to IL-1R, thus minimize the proinflammatory effects of IL-1 [107]."
33278517
sparser
"The first signaling pathway scenario is induced by IL-38/ IL-1R1 axis in which IL-1α and IL-1β bind to IL-1R1 and consequently activate the corresponding pathway. can bind to IL-1RAPL1 and consequently prohibit the JNK/AP1 pathway."
35260945
sparser
"Binding of the agonists IL-1α or IL-1β to IL-1R1 results in conformational changes of the receptor and in the formation of IL-1R1/IL-1R3 complexes ( xref ) [ xref , xref , xref ]."
30042333
sparser
"IL-1Ra inhibits the binding of IL-1α and IL-1β to IL-1R1."
31185596
sparser
"It blocks the binding of IL-1β and IL-1α to their receptor IL-1R and hence blocks IL-1 activity [68]."
32663575
sparser
"For ligands that bind IL-1R1, IL-1β, and IL-1α, Anakinra has been FDA approved for the treatment of rheumatoid arthritis and for the treatment of neonatal-onset multisystem inflammatory disease ( xref )."
28303241
sparser
"IL-1RA, an antagonist of the IL-1R signaling pathway, functions by interfering with the binding of IL-1α and IL-1β to IL-1R ( xref )."
20802527