IndraLab

Statements

IL-1α binds IL1B and IL1R1. 41 / 41
| 41
sparser
"Because mice deficient in the IL-1R cannot respond to IL-1, this result demonstrated that either IL-1α or IL-1β, both of which bind to the IL-1R, contributed to acute pathology after rVSV immunization."
23056330
sparser
"Anakinra is an IL-1R antagonist that inhibits the binding of IL-1α and IL-1β to IL-1R and prevents inflammation [ xref ]."
25852877
sparser
"Importantly, IL-1α and IL-1β both bind the IL-1R, but the role for IL-1α is poorly understood in most disease conditions."
31186281
sparser
"IL-1Ra inhibits the binding of IL-1α and IL-1β to IL-1R1."
31185596
sparser
"Both IL-1α and IL-1β bind to IL-1R1 and form an activating complex with the signaling chain IL-1R3."
28642703
sparser
"Anakinra as IL-1RA binds to the IL-1R and consequently prevents the binding of IL-1α as well as IL-1β to IL-1R1 and blocks their activity [ xref , xref ]."
34063964
sparser
"Anakinra blocks the binding of both IL-1α and IL-1β to IL-1R, thereby inhibits the proinflammatory effects of IL-1 [ xref ]."
| PMC
sparser
"Anakinra was the first recombinant IL-1R antagonist (rHIL-1Ra) that blocks the binding of both IL-1α and IL-1β to IL-1R, thus minimize the proinflammatory effects of IL-1 [ xref ]."
33278517
sparser
"Blocking IL-1 entered the clinical arena with anakinra, the recombinant form of the naturally occurring IL-1 receptor antagonist (IL-1Ra); IL-1Ra prevents the binding of IL-1α as well as IL-1β to IL-1R1."
30459597
sparser
"IL-1R1, which binds to both IL-1α and IL-1β, can be detected in a variety of cell types, whereas the IL-1R2 is found on the cell surface of type B lymphocytes, neutrophils and macrophage, and binds with IL-1β with higher affinity[ xref ]."
24006091
sparser
"Both IL-1α and IL-1β bind to same IL-1R, and bone marrow-derived macrophages produced both IL-1α and IL-1β in response to LCWE in vitro ( xref )."
26941015
sparser
"IL-1α and IL-1β both bind the IL-1R, which is critical for control of L. pneumophila infection."
31351897
sparser
"By mirroring the mode of action of the endogenous form, anakinra inhibits the binding of IL-1α and IL-1β to IL-1R, and it has been approved for the treatment of rheumatoid arthritis, adult-onset Still’s disease, and certain periodic fever syndromes (such as familial Mediterranean fever)."
33110739
sparser
"The IL-1 pathway is triggered when the ligands IL-1α and IL-1β bind to IL-1R1, which forms a complex with the IL-1 receptor accessory protein (IL-1RAcP) xref ."
32206125
sparser
"Although both IL-1α and IL-1β can interact with IL-1R1 to induce downstream transcription of inflammatory genes, they show considerable differences in their localization, regulation, and function."
28706254
sparser
"IL-1Ra, encoded by IL-1RN , can also compete with the binding of IL-1α and IL-1β to the IL-1R complex."
32067109
sparser
"It inhibits the signaling pathways through activated IL-1R by interrupting interaction of IL-1α and IL-1β with IL-1R [ xref ]."
33572274
sparser
"Indeed, it is true that recombinant IL-1α and IL-1β both bind to IL-1R to induce a proinflammatory signaling cascade."
23087690
sparser
"IL-1ra is a cytokine produced by monocytes, macrophages, and dendritic cells, which prevents the binding of IL-1α as well as IL-1β to IL-1R1 by competitively blocking IL-1RI receptors [ xref , xref ]."
32384874
sparser
"IL-1α and IL-1β bind specifically to IL-1R1, IL-18 to IL-18Rα, IL-33 to ST2 and IL-36α, IL-36β, and IL-36γ to IL-36R ( xref )."
33796114
sparser
"Although they are structurally very different, both IL-1α and IL-1β bind to the IL-1Rs and the neurochemical effects of both forms are similar ( xref )."
30013513
sparser
"After binding of IL-1α or IL-1β to the IL-1R1, a complex signaling cascade is activated, eventually leading to “nuclear factor kappa-light-chain-enhancer of activated B cells” (NFκB) production and subsequent gene transcription [ xref ]."
28109186
sparser
"IL-1α and IL-1β bind to the IL-1R, which induces the release of chemokines and recruitment of neutrophils xref , xref ."
25760420
sparser
"For ligands that bind IL-1R1, IL-1β, and IL-1α, Anakinra has been FDA approved for the treatment of rheumatoid arthritis and for the treatment of neonatal-onset multisystem inflammatory disease ( xref )."
28303241
sparser
"When IL-1α or IL-1β bind to IL-1R1, a structural change occurs so that IL-1R3 interacts with IL-1R1 forming a heterotrimeric complex thereby initiating intracellular signalling."
36209522
sparser
"IL-1RA, an antagonist of the IL-1R signaling pathway, functions by interfering with the binding of IL-1α and IL-1β to IL-1R ( xref )."
20802527
sparser
"Two isoforms of IL-1 exist, IL-1α and IL-1β, which bind the same receptor IL-1R but are encoded by two different genes."
34604096
sparser
"ST2 is a member of the IL-1 receptor family; it was originally identified as being induced by serum or oncogene expression in mouse fibroblasts ( xref , xref ), and it does not bind IL-1α, IL-1β, or IL-1R antagonist ( xref – xref )."
28114842
sparser
"IL-1α and IL-1β bind to IL-1R1, leading to the activation of IL-1 signal-regulated innate immune and inflammatory physiological functions."
28585438
sparser
"Following binding of IL-1α or IL-1β to the type I IL-1R, a second protein, the IL-1 receptor accessory protein (AcP), is recruited to the complex (Greenfeder et al., 1995) ."
12530978
sparser
"Binding of the agonists IL-1α or IL-1β to IL-1R1 results in conformational changes of the receptor and in the formation of IL-1R1/IL-1R3 complexes ( xref ) [ xref , xref , xref ]."
30042333
sparser
"Both IL-1α and IL-1β bind to IL-1R1, thereby enabling recruitment of its co-receptor IL-1RAc."
32550001
sparser
"It blocks the binding of IL-1β and IL-1α to their receptor IL-1R and hence blocks IL-1 activity [ xref ]."
32663575
sparser
"It can block the binding of both IL-1α and IL-1β to IL-1R [ xref ]."
33608746
sparser
"IL-1RA blocks the binding of IL-1α and IL-1β to IL-1R1, having no cross-reactivity with IL-1α and IL-1β [ xref ]."
35048046
sparser
"IL-1α and IL-1β bind to IL-1R1 complexed to the IL-1 receptor accessory protein and induce similar physiological effects."
25764208
sparser
"Initiating intracellular signaling via the IL-1R1 system is a multistep process involving: IL-1α or IL-1β binding to the extracellular domain of IL-1R1, recruitment of accessory proteins (e.g., the co-receptor IL-1R1 accessory protein (IL-1RAcP)), formation of a receptor heterodimeric complex (comprised of IL-1α or IL-1β, IL-1RI, and IL-1RAcP), and assemblage of intracellular adaptor proteins."
25479427
sparser
"Binding of IL-1R1 with IL-1α or IL-1β leads to subsequent recruitment of IL-1RAcP at the cell membrane [ xref ] and downstream cytosolic NF-κB activation."
25706624
sparser
"When either IL-1β or IL-1α binds to IL-1R1, a structural change takes place allowing IL-1R3 to bind and to form a heterotrimeric complex ( xref )."
32324502
sparser
"As IL-1α and IL-1β both bind to the IL-1R and are antagonized by Anakinra, ASC-independent release of IL-1α may make an important contribution to DDA/TDB-induced Th induction."
23308247
sparser
"In contrast, IL-1Ra acts as an antagonist of IL-1R1, preventing the binding of IL-1α and IL-1β with IL-1R1, respectively."
27294501