IndraLab

Statements

Phosphorylated TP53 is active. 6 / 6
5 | 1
signor
"Atm/atr are generally sensors of dna damage, but, together with the checkpoint kinases chk1 and chk2, they also function as response effectors by phosphorylation of key substrates, such as p53, brca1, and nbs1. In particular, p53 phosphorylation leads to protein accumulation and activation, which in turn promotes cell-cycle arrest or apoptosis."
17157788
signor
"Furthermore, we show that prak activates p53 by direct phosphorylation. We propose that phosphorylation of p53 by prak following activation of p38 mapk by ras plays an important role in ras-induced senescence and tumor suppression."
17254968
trips
"active phospho-p53"
21092747
signor
"Activated jnk phosphorylates p53"
9724739
signor
"We show that prak activates p53 by direct phosphorylation."
17254968
signor
"The targets of jnk include the transcription factors p53. P75ntr-mediated apoptosis was shown to be dependent of p53"
14699954