IndraLab

Statements

AKT activates USP4. 3 / 3
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"Based on this study, it would be interesting to investigate whether USP4 function, which is also modulated by AKT as described above, is also affected in CYLD knockout mice XREF_BIBR."
25007997
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"According to a previous study by Iyengar [XREF_BIBR], Akt promotes USP4 to enter the cell membrane and cytoplasm to phosphorylate USP4 and regulate its subcellular localization, and Akt phosphorylation of USP4 occurs by combining with other de-ubiquitinating enzymes (DUBs) to de-ubiquitinate the TGF-beta receptor [XREF_BIBR]."
32308208
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"This study suggests that Akt activation in breast cancer cells induces USP4 to relocate and stabilize TbetaRI in the plasma membrane, and thereby enforces TGF-beta-induced pro tumorigenic responses."
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