IndraLab

Statements

EDN1 activates EGFR. 3 / 3
3 |
bel
"Modified assertion"
15269139
bel
"Besides being activated by ligand binding, the EGFR can be transactivated by a growing number of different pathways, including G-protein-coupled receptors (GPCRs), cytokine receptors, ion channels, integrins, and other RTKs.37"
11795306
bel
"Treatment of cells with GPCR agonists such as endothelin- 1 (ET-1), thrombin, bombesin, and lysophosphatidic acid (LPA) transactivates ErbB1 (reviewed by Zwick et al. [48]). Mechanistically, the process involves rapid stimulation of metalloproteinases followed by cleavage of an ErbB1 ligand precursor, e.g., pro-HB-EGF [49], whose binding activates ErbB1 and downstream signaling pathways"
12648469