IndraLab

Statements

KCNMA1 activates thiocyanate. 5 / 5
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"Specifically, Kcnma1 -/- mice have increased spontaneous firing rates in SCN neurons at night, implying that the nightly BK current might reduce SCN spike frequency."
22877662
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"BK channel-null mice (Kcnma1 (-/-)) have increased SFRs in SCN neurons selectively at night and weak circadian amplitudes in multiple behaviors timed by the SCN."
16845385
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"Because these data demonstrate that the predominant Ca 2+ source for BK channel activation in SCN neurons changes with the circadian cycle, from primarily requiring LTCCs during the day, to primarily requiring RyR mediated Ca 2+ release at night, it opens the question of whether BK channels may dynamically couple and uncouple from their Ca 2+ sources over the circadian cycle."
29237755
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"Block of BK channels or deletion of Kcnma1, the gene encoding the pore forming subunit of the BK channel, increases nighttime firing in SCN neurons, although not completely abolishing the day-night difference in SFR XREF_BIBR, XREF_BIBR."
19060951
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"To determine whether diurnal regulation of [Ca 2+] i was relevant for BK channel activation in SCN, we used a pharmacological approach to identify the Ca 2+ sources for BK current activation during the day and night in acute SCN slices."
27481715