IndraLab

Statements

SPATA2 binds OTULIN and CYLD. 4 / 4
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sparser
"LUBAC exists in distinct complexes with the DUBs OTULIN (1) and CYLD-SPATA2 (2)."
33473179
sparser
"Fig. 2: LUBAC exists in distinct complexes with the DUBs OTULIN (1) and CYLD-SPATA2 (2)."
33473179
sparser
"The mechanisms regulating the interaction of LUBAC with OTULIN and SPATA2-CYLD in cells are not well-understood but in vitro studies show that phosphorylation of the tyrosine (Y56) in the OTULIN PIM abrogates its interaction with HOIP, suggesting that this may be a mechanism to regulate the LUBAC–OTULIN complex [32]."
33473179
sparser
"The mechanisms regulating the interaction of LUBAC with OTULIN and SPATA2-CYLD in cells are not well-understood but in vitro studies show that phosphorylation of the tyrosine (Y56) in the OTULIN PIM abrogates its interaction with HOIP, suggesting that this may be a mechanism to regulate the LUBAC–OTULIN complex [ xref ]."
33473179