IndraLab

Statements

USP28 activates Ubiquitin. 8 / 8
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"USP28 has also been reported to antagonize ubiquitin-dependent degradation of the oncogene product MYC as well as JUN and Notch ."
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"USP28 could modulate the lifespan of c-Myc, c-JUN, Notch1, and ΔNp63 through erasing ubiquitin modifications from them [ 8 , 9 ]."
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"Additionally, a deubiquitinase, USP28, has been reported to antagonize ubiquitin dependent proteasomal degradation of c-Myc."
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"We transfected HeLa cells with FLAG tagged Myc or Fbw7 together with HA tagged ubiquitin and increasing amounts of Usp28 and recovered ubiquitinated proteins by immunoprecipitation."
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"Here, using murine genetic models, we determined that USP28 antagonizes the ubiquitin dependent degradation of c-MYC, a known USP28 substrate, as well as 2 additional oncogenic factors, c-JUN and NOTCH1, in the intestine."
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"Interestingly, USP28 can also antagonize the ubiquitin dependent degradation of two additional oncogenic proteins, c-Jun and Notch1, expanding the substrate list that is shared by both USP28 and FBW7."
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"These results showed that the UIM of USP28 most likely enhances the cleavage of Ub chains by binding to the proximal Ub of K11-linked di-Ub and positioning the substrate correctly in the active site."
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"USP28 antagonizes the Ub-dependent degradation of c-myc, as well as c-Jun and Notch, by targeting the Ub ligase Fbw7, thereby stabilizing the HIF-1α transcription factor [66] ."
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