IndraLab

Statements

USP8 activates FLIP. 2 / 2
| 2
reach
"Loss of PTEN function (right panel, XREF_FIG), in contrast increases pAkt levels, decreases USP8 levels, and turns off the USP8 and AIP4 ubiquitin switch, allowing FLIP S to accumulate and suppress TRAIL induced apoptosis."
20484045
reach
"Because PTEN dependent regulation of FLIP S stability is mediated by changes in FLIP S ubiquitination, we took the above USP8 modulated cells, transiently transfected a construct encoding HA tagged ubiquitin, and following FLIP S immunoprecipitation used Western blot analysis to monitor the effect of USP8 alteration on the extent of HA-ubiquitin incorporated into FLIP S."
20484045