IndraLab

Statements

SPATA2 binds OTULIN. 4 / 5
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sparser
"OTULIN and SPATA2 bind the same PIM pocket in HOIP, which excludes the simultaneous binding of both proteins to LUBAC and gives rise to two distinct LUBAC–DUB complexes; LUBAC–OTULIN and LUBAC–SPATA2–CYLD [11, 31] (Fig. 2)."
33473179
sparser
"OTULIN-released LUBAC interacts with SPATA2 and is recruited to the TNF-R1sc, facilitating SPATA2-CYLD interaction."
35958947
sparser
"OTULIN and SPATA2 bind the same PIM pocket in HOIP, which excludes the simultaneous binding of both proteins to LUBAC and gives rise to two distinct LUBAC–DUB complexes; LUBAC–OTULIN and LUBAC–SPATA2–CYLD [ xref , xref ] (Fig.  xref )."
33473179
sparser
"Because the N102A mutation in the PUB domain of HOIP abolishes the interaction with OTULIN and SPATA2, we assumed that, similar to OTULIN, SPATA2 might also contain a PUB-domain interacting motif (PIM)."
27545878