IndraLab

Statements

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"Moreover, depletion of another DUB, PSMD14, significantly decreased tumorigenesis of CRC cells in a xenograft model, and its expression was correlated with malignant progression and survival of CRC patients [147]."
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"Besides, PSMD14 depletion significantly decreased tumorigenesis of colorectal cancer cells as well as cancer stemness [ 19 ]."
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"PSMD14 could facilitate breast cancer progression through ERalpha signaling in vitro and in vivo, while pharmaceutical inhibition of PSMD14 via Thiolutin could block the tumorigenesis in breast cancer."
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"Deubiquitinating enzyme PSMD14 could promote carcinogenesis by stabilizing PTBP1 in STAD."
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"The findings above demonstrate that PSMD14 may promote cancer carcinogenesis."
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"A work from Qin et al. found cornification related protein, Peptidylargininedeiminase 1 or PAD1, could promote tumorigenesis by regulating MEK1-ERK1/2-MMP2 signaling in triple negative breast cancer.41 Another work from Fiskin revealed disrupted cornification could induce immune dysfunction state in human skin, which were consistent with our finding that TDERS high group with cornification activated state resulted with immune dysfunction."
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