IndraLab

Statements

CYLD activates TRAF6. 7 / 7
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"The deubiquitinating enzymes A20 and CYLD inhibit NF-kappaB signaling by targeting TRAF6 upstream of IKK, while a recent report shows that CUEDC2 inhibits IKK activity by recruiting a phosphatase PP1 and keeps IKK in an inactivated status."
21703539
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"CYLD has been shown to target TRAF6, TRAF2, and NEMO for deubiquitination, thus presumably reduced their activities in NF-kappaB activation."
22649774
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"40 RANKL stimulated osteoclastogenesis potently induces the expression of CYLD, and the accumulated CYLD targets TRAF6 by interacting with the adaptor protein, p62."
19373246
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"More importantly, we showed that TRAF-6-mediated over-expression of PAI-1 was inhibited by co-expression of wt-CYLD in S. p -infected A549 cells, suggesting that CYLD may target TRAF-6 in inhibiting P[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26056944
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"It has been shown that the tumor suppressor CYLD targets TRAF6 for deubiquitination to terminate TLR triggered activation of NF-kappaB XREF_BIBR XREF_BIBR."
27586056
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"It has been demonstrated that the deubiquitinating enzymes A20 and CYLD inhibit NF-kappaB signaling by targeting TRAF6 upstream of IKK, while the deubiquitinating protein DUBA inhibits type I interferon activity by targeting TRAF3."
20434986
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"Thus, it is possible that CYLD functions in diverse pathways and loss of CYLD activity contributes to tumorigenesis via multiple mechanisms.Lys63-linked ubiquitin chains, synthesized in response to cy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18313383