IndraLab

Statements

CYLD leads to the ubiquitination of MAP3K7. 4 / 4
| 4
reach
"CYLD also downregulates Streptococcus pneumoniae induced NFAT (nuclear factor for activated T cells) activation and inflammation by inhibiting TAK1 ubiquitination."
22435550
reach
"The deubiquitinase CYLD also impairs T-cell activation via NF-κB, but in this case by deubiquitinating Lys63-ubiquitin chains from the TAK1 kinase downstream of the CBM complex (Figure 2)."
| PMC
reach
"Inclusion of Cyld (WT) (XREF_FIG, lane3) but not Cyld (C601A) mutant (XREF_FIG, lane4) that lacks the DUB activity 37 resulted in diminished Tak1 ubiquitination suggesting that Cyld deubiquitinated Tak1."
22057290
reach
"CYLD has been shown to prevent spontaneous NF-kappaB activation in T cells in the absence of receptor engagement by inhibiting the ubiquitination and autoactivation of TAK1."
21145487