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USP10 inhibits c-Myc oncogene. 4 / 4
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"30 In addition, previous studies have demonstrated that USP10 antagonizes the transcriptional activity of the c-Myc oncogene through Sirt6 to inhibit cell cycle progression, cell growth, and tumor formation in human colon cancers."
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"They also reported that USP10 antagonized the transcriptional activity of the c-Myc oncogene through SIRT6, as well as p53, thereby inhibiting cell cycle progression, cancer cell growth, and tumoral f[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Because one of the molecular mechanisms by which SIRT6 achieves its tumor suppressive functions is through c-Myc inhibition, our results suggest that USP10 inhibits the c-Myc oncogene, at least partially, through SIRT6 stabilization."
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"USP10 antagonizes the transcriptional activity of the c-Myc oncogene through SIRT6, as well as p53, to inhibit cell cycle progression, cancer cell growth, and tumor formation."
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