IndraLab

Statements

KCNA5 inhibits PSMD4. 4 / 4
| 4
reach
"Further, loss-of-function mutation in KCNA5 has been shown to cause AF in humans 8."
24508725
reach
"Loss-of-function mutations in the related voltage gated potassium channel KCNA5 unexpectedly lead to AF by an atypical mechanism involving decreased I Kur which leads to a predisposition for atrial action potential prolongation and early after-depolarizations [XREF_BIBR, XREF_BIBR]."
26162324
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"Since both gain and loss-of-function mutations in KCNA5 can cause AF, it may be postulated that this must be based on distinct mechanisms."
28729840
reach
"Recent studies however have shown that loss-of-function mutations in KCNA5, the gene that encodes K V 1.5, the alpha subunit of the I Kur channel, is associated with the development of AF and that inhibition of I Kur can promote the induction of AF in experimental models."
19698954