IndraLab

Statements

TNF phosphorylates CYLD. 4 / 4
| 3 1
reach
"Although TNF was previously shown to trigger CYLD phosphorylation in Jurkat, HeLa, or HEK 293 cells, leading to the appearance of a slower migrating form of CYLD, stimulation of our Jurkat T cells with TNF did not lead to a band shift or detection of a band with the phospho (Ser418)-specific antibody, suggesting either no phosphorylation or phosphorylation at other sites."
29755980
sparser
"While the phosphorylation of A20, CYLD and p38 induced by TNFα was largely unaffected by ABIN-1 deficiency ( xref ), using an anti-phospho-S381 A20 antibody xref , the recruitment of phospho-A20 to TNF-RSC was significantly reduced inAbin-1 −/− MEFs compared to that of WT ( xref )."
29203883
reach
"The phosphorylated residue Ser568 is a novel tumor necrosis factor (TNF)-regulated phosphorylation site in CYLD and works in concert with Ser418 to enable CYLD-mediated deubiquitination and immune receptor signaling."
34610306
reach
"We have previously shown that induction of CYLD phosphorylation by TNF-alpha or mitogens is mediated by the IKK complex [XREF_BIBR]."
21824392