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EGFR phosphorylates PLCG1. 39 / 40
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"To examine the direct interaction between tyrosine-phosphorylated PLC-γ1 and Grb2, purified PLC-γ1 was tyrosine-phosphorylated by EGFR in vitro and the phosphorylated PLC-γ1 (pPLC-γ1) was isolated ( F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16038803
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"Tyrosine phosphorylation of PLC-γ1 by the EGF receptor is crucial for the enzymatic activation of PLC-γ1 [21,26] ."
11226408
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"In response to EGF stimulation, the SH2 domains of PLCγ1 bind to the autophosphorylated EGFR Y992, which leads to phosphorylation and activation of PLCγ1 by EGFR ( xref )."
23123196
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"PLCγ-1 is phosphorylated by EGFR on ligand stimulation ( xref )."
18594017
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"In response to EGF stimulation, the SH2 domains of PLCgamma1 bind to the autophosphorylated EGFR Y992, which leads to phosphorylation and activation of PLCgamma1 by EGFR."
23123196
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"In this assay, PLCγ1 was phosphorylated by the epidermal growth factor receptor (EGFR) and used as a substrate for PTPμ. xref shows that with increasing amounts of WT PTPμ there is a clear decrease in the tyrosine phosphorylation of PLCγ1 as well as a dramatic shift downward in the mobility of the protein, which is consistent with its dephosphorylation."
20506511
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"Epidermal growth factor receptor (EGFR) -induced tyrosine phosphorylation of PLC-gamma1 resulted in resistance to cleavage by caspase-3 in vitro."
10834929
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"This observation suggests a direct phosphorylation of PLC-gamma1 by EIR-2, like the phosphorylation of PLC-gamma1 by the wt-EGFR."
10350617
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"In the current study, we showed that Grb2 directly interacts with phosphotyrosine residue (Tyr 783 ) of PLC-γ1 which was phosphorylated by EGFR."
16038803
sparser
"The immunopurified PLC-γ1 was tyrosine-phosphorylated by EGFR in vitro and the phosphorylated PLC-γ1 was isolated and incubated with GST-Grb2 WT ( Fig. 2 C)."
16038803
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"In the present study we demonstrated that BPQs not only induced EGFR tyrosine autophosphorylation, but also induced EGFR-dependent tyrosine phosphorylation of phospholipase C-γ1 and several signal transducers and activators of transcription (STATs)."
19166869
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"These findings show that the EGF receptor can directly phosphorylate PLC-II in an efficient and selective manner."
2732223
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"The EGF receptor phosphorylates PLC-γ1 at three tyrosines (771, 783 and 1254 [ xref ]), at least two of which (Y783 and Y1254) are required for maximal activation."
23144648
biopax:netpath
No evidence text available
7926042
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"PLCgamma-1 is phosphorylated by EGFR on ligand stimulation."
18594017
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"Upon EGF stimulation, activated EGFR recruits and subsequently phosphorylates PLC-γ1."
16038803
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"Furthermore, cleaved PLC-gamma1 could not be tyrosine-phosphorylated by EGFR in vitro."
10834929
trips
"These findings show that the EGF receptor can directly phosphorylate PLC-II in an efficient and selective manner."
2732223
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"This suggests that the EGF receptor can phosphorylate PLC-γ1 properly even when the EGF receptor is delocalized from CM."
11226408
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"Phospholipase Cγ1 (PLCγ1) can also be recruited directly through phosphotyrosine residues of growth factor receptors that serve as PLCγ1 docking sites xref , leading to PLCγ1 phosphorylation by EGFR and activation of DAG and IP3 signaling ( xref )."
29628996
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"Additional data indicated that PLC-gamma 1 binds to RACKs in solution; epidermal growth factor receptor-dependent PLC-gamma 1 phosphorylation and activation decreased in the presence of RACKs."
8290562
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"In the current study, we showed that Grb2 directly interacts with phosphotyrosine residue (Tyr 783) of PLC-gamma1 which was phosphorylated by EGFR."
16038803
reach
"PLC-gamma1 binds directly to the autophosphorylated EGFR via Y1173 and Y992 and is phosphorylated by EGFR kinase."
19166869
reach
"The EGF receptor phosphorylates PLC-gamma1 at three tyrosines, at least two of which (Y783 and Y1254) are required for maximal activation."
23144648
reach
"These differences, along with the finding that EGFR trans-phosphorylates PLC-γ1 molecules bound to the cytosolic tail of PD-L1, may relate to the allele-specific resistance of EGFR tumors to ICBs.Although short and lacking enzymatic activity, the cytoplasmic domain of PD-L1 mediates a plethora of cellular functions."
34038737
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"Both basal and autophosphorylated forms of the purified EGF receptor increased the activity of the non-tyrosine-phosphorylated PLC-gamma 1, and stoichiometric levels of purified receptor were required to increase PLC activity."
8343130
sparser
"In the present study we demonstrated that BPQs not only induced EGFR tyrosine autophosphorylation, but also induced EGFR-dependent tyrosine phosphorylation of phospholipase C-gamma1 and several signal transducers and activators of transcription (STATs)."
19166869
sparser
"Based on these findings, it is suggested that PLC-γ1 can be phosphorylated at Ser by EGF receptor or β2-adrenergic receptor through the activation of PKA."
12123716
reach
"These findings show that the EGF receptor can directly phosphorylate PLC-II in an efficient and selective manner."
2732223
reach
"This suggests that the EGF receptor can phosphorylate PLC-gamma1 properly even when the EGF receptor is delocalized from CM."
11226408
sparser
"Phosphorylation of phospholipase C-gamma 1 by the epidermal growth factor receptor tyrosine kinase overcomes the inhibitory effect of profilin and results in an effective activation of phospholipase C-gamma 1."
1848725
reach
"In this assay, PLCgamma1 was phosphorylated by the epidermal growth factor receptor (EGFR) and used as a substrate for PTPmu."
20506511
reach
"It has also been observed that the purified EGFR increased the activity of non-tyrosine-phosphorylated PLC- gamma 1 to a much greater extent than the phosphorylated form in vitro [24]."
9194574
rlimsp
"We developed an automated, continuous quench-flow system allowing quantitative proteomic assessment of very early cellular signaling events (qPACE) with a time resolution of 1 s. Using this technique, we determined that autophosphorylation of the epidermal growth factor receptor occurs within 1 s after ligand stimulation and is followed rapidly by phosphorylation of the downstream signaling intermediates Src homologous and collagen-like protein and phospholipase C gamma 1."
17450129
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"The biological activities were converted into the corresponding pIC values (−log IC), where IC value represents the drug in molar concentration that causes 50% inhibition of phopholipase Cγ1 phosphory[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14527561
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"Phospholipase Cgamma1 (PLCgamma1) can also be recruited directly through phosphotyrosine residues of growth factor receptors that serve as PLCgamma1 docking sites XREF_BIBR, leading to PLCgamma1 phosphorylation by EGFR and activation of DAG and IP3 signaling (XREF_FIG)."
29628996
biopax:netpath
No evidence text available
1730638
biopax:netpath
No evidence text available
14500405
sparser
"This suggests that the phosphorylation of PLC-γ1 by EGFR and its subsequent translocation into the nucleus is required for the expression of these nuclear signaling events as also implied by the dependency of p120 knockdown on proliferation and PLC-γ1."
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