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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

Modified MDM2 inhibits TP53. 3 / 3
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"On the other hand, Mdm2 over-expression in cancer cells negatively regulates p53 levels and increased Mdm2 levels would probably abrogate any inhibitory effect of p53 on the CMV promoter activity."
"We found that the ectopic expression of MDM2 downregulated the cellular levels of Vif as well as p53 in transfected cells in a dose dependent manner, whereas Parkin and Cul5 did not affect their cellular levels (lanes 2-4 and 5-7, respectively), even though the latter proteins were expressed more than MDM2."
"Mdm2 is an E3 ubiquitin ligase that targets p53 for mono- and poly-ubiquitination Monoubiquitination mediated by low levels of Mdm2 promotes mitochondrial localization of p53, and elevates nuclear export of p53 to block its transactivational activity; high Mdm2 levels promote polyubiquitination and subsequent proteasome dependent degradation of p53 [XREF_BIBR]."