IndraLab
Statements
reach
"Mdm2 is an E3 ubiquitin ligase that targets p53 for mono- and poly-ubiquitination Monoubiquitination mediated by low levels of Mdm2 promotes mitochondrial localization of p53, and elevates nuclear export of p53 to block its transactivational activity; high Mdm2 levels promote polyubiquitination and subsequent proteasome dependent degradation of p53 [XREF_BIBR]."
reach
"We found that the ectopic expression of MDM2 downregulated the cellular levels of Vif as well as p53 in transfected cells in a dose dependent manner, whereas Parkin and Cul5 did not affect their cellular levels (lanes 2-4 and 5-7, respectively), even though the latter proteins were expressed more than MDM2."