IndraLab

Statements


Modified MDM2 inhibits TP53. 4 / 4
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"Mdm2 is an E3 ubiquitin ligase that targets p53 for mono- and poly-ubiquitination Monoubiquitination mediated by low levels of Mdm2 promotes mitochondrial localization of p53, and elevates nuclear export of p53 to block its transactivational activity; high Mdm2 levels promote polyubiquitination and subsequent proteasome dependent degradation of p53 [XREF_BIBR]."

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"On the other hand, Mdm2 over-expression in cancer cells negatively regulates p53 levels and increased Mdm2 levels would probably abrogate any inhibitory effect of p53 on the CMV promoter activity."

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"Increased expression of Mdm2 is found to reduce the steady state levels of p53 and decrease the stability of p53 without affecting p53 mRNA levels."

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"We found that the ectopic expression of MDM2 downregulated the cellular levels of Vif as well as p53 in transfected cells in a dose dependent manner, whereas Parkin and Cul5 did not affect their cellular levels (lanes 2-4 and 5-7, respectively), even though the latter proteins were expressed more than MDM2."