IndraLab

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IFNG activates USP18. 5 / 5
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"2 In addition, USP18 has been found to inhibit TRAIL-induced apoptosis independently of the deISGylation pathway.91 Furthermore, the depletion of USP18 leads to a strong increase in the levels and activity of miR-7, and this activity in turn decreases the expression of EGFR, leading to apoptosis and control of cancer cells.92Hong et al.93 found that IFN-γ can induce USP18 in tumor cells and that this protein plays an important role in inhibiting tumorigenesis and maintaining antitumor immunity."
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"92 Hong et al. 93 found that IFN-gamma can induce USP18 in tumor cells and that this protein plays an important role in inhibiting tumorigenesis and maintaining antitumor immunity."
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"The novel finding in this study is the discovery that the ubiquitin specific peptidase USP18 can be induced by IFN-gamma in tumor cells and plays important roles in inhibiting tumorigenesis and antitumor immunity."
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"92 Hong et al. 93 found that IFN-γ can induce USP18 in tumor cells and that this protein plays an important role in inhibiting tumorigenesis and maintaining antitumor immunity."
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"The low-level induction of USP18 by IFN-gamma was not sufficient to attenuate (peg) IFN-alpha-mediated signaling."
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