IndraLab

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SCN8A binds CELF4. 3 / 3
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"As part of a related study, we find that CELF4 directly binds Scn8a mRNA, encoding sodium channel Na (v) 1.6, the primary instigator of AP at the axon initial segment (AIS) and the main carrier of I (NaP)."
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"CELF4 binds Scn8a mRNA and in the absence of CELF4, Nav1.6 channels are dramatically overexpressed at axon initial segments suggesting they may play a role in seizure generation by increasing action potential initiation in this model [XREF_BIBR]."
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"Such effects may well be related to function in the pyramidal neuron AIS, as Na V 1.6 expression is significantly higher in epileptic mice deficient for CELF4, an RNA binding protein that binds to Scn8a mRNA [XREF_BIBR]."
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