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USP10 leads to the dephosphorylation of AKT. 2 / 2
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"Collectively, our results uncover an undescribed mechanism where USP10, as a tumor suppressor, negatively regulates mTORC1 activation and AKT phosphorylation by stabilizing AMPKalpha and PTEN in HCC cells."
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"Additionally, the MK2206 and rapamycin significantly suppressed AKT phosphorylation and mTOR complex1 activation in USP10 knockdowned HCC cells, may indicate that AKT inhibitor and rapamycin can be co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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